Supramolecular (Bio)Materials

MIXED REVERSIBLE COVALENT CROSSLINK KINETICS ENABLE PRECISE, HIERARCHICAL MECHANICAL TUNING OF HYDROGEL NETWORKS

Yesilyurt, V.^; Ayoob, A.M.^; Appel, E.A.; Borenstein, J.T.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF

SINGLE-CHAIN POLYMERIC NANOCARRIERS: A PLATFORM FOR DETERMINING STRUCTURE-FUNCTION CORRELATIONS IN THE DELIVERY OF MOLECULAR CARGO

Chan, D.; Yu, A.; Appel, E.A.* Biomacromolecules (2017) PDF

SYNTHESIS AND BIOLOGICAL EVALUATION OF IONIZABLE LIPID MATERIALS FOR THE IN VIVO DELIVERY OF MESSENGER RNA TO B LYMPHOCYTES

Fenton, O.S.; Kauffman, K.J.; Kaczmarek, J.C.; McClellan, R.L.; Jhunjhunwala, S.; Tibbitt, M.W.; Zeng, M.D.; Appel, E.A.; Dorkin, J.R.; Mir, F.F.; Yang, J.H.; Oberli, M.A.; Heartlein, M.W.; DeRosa, R.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF

DECOUPLED ASSOCIATIVE AND DISSOCIATIVE PROCESSES IN HIGHLY DYNAMIC HOST-GUEST COMPLEXES

Appel, E.A.*; Biedermann, F.*; Hoogland, D.; del Barrio, J.; Driscoll, M.D.; Hay, S.; Wales, D.J.; Scherman, O.A.* Journal of the American Chemical Society (2017) PDF

DISTINGUISHING RELAXATION DYNAMICS IN TRANSIENTLY CROSSLINKED POLYMERIC NETWORKS

Tan, C.S.Y.; Agmon, G.; Liu, J.; Hoogland, D.; Janecek, E.-R.; Appel, E.A.*; Scherman, O.A.* Polymer Chemistry (2017) PDF

MECHANISTIC UNDERSTANDING OF IN VIVO PROTEIN CORONA FORMATION ON POLYMERIC NANOPARTICLES AND IMPACT ON PHARMACOKINETICS

Bertrand, N.; Grenier, P.; Mahmoudi, M.; Lima, E.; Appel, E.A.; Dormont, F.; Lim, J.-M.; Karnik, R.; Langer, R.; Farokhzad, O.* Nature Communications (2017) PDF

SUPRAMOLECULAR POLYMERIC BIOMATERIALS

Mann, J.L.^; Yu, A.C.^; Agmon, G.; Appel, E.A.* Biomaterials Science (2017) PDF

ENGINEERING THE MECHANICAL PROPERTIES OF POLYMER NETWORKS WITH PRECISE DOPING OF PRIMARY DEFECTS

Chan, D.; Ding, Y.; Dauskardt, R.H.; Appel, E.A.* ACS Applied Materials and Interfaces (2017) PDF

SCALABLE MANUFACTURING OF BIOMIMETIC MOLDABLE HYDROGELS FOR INDUSTRIAL APPLICATIONS

Yu, A.C.; Chen, H.; Chan, D.; Agmon, G.; Stapleton, L.M.; Sevit, A.M.; Tibbitt, M.W.; Acosta, J.D.; Zhang, T.; Franzia, P.W.; Langer, R.; Appel, E.A.* Proceedings of the National Academy of Sciences (2016) PDF

SUPRAMOLECULAR BIOMATERIALS

Webber, M.J.^; Appel, E.A.^; Meijer, E.W.; Langer, R.* Nature Materials (2016) PDF

SUPRAMOLECULAR PEGYLATION OF BIOPHARMACEUTICALS

Webber, M.J.^; Appel, E.A.^; Vinciguerra, B.; Thapa, L.S.; Cortinas, A.B.; Jhunjhunwala, S.; Isaacs, L.*; Langer, R.*; Anderson, D.G.* Proceedings of the National Academy of Sciences (2016) PDF

BIOINSPIRED ALKENYL AMINO ALCOHOL IONIZABLE LIPID MATERIALS FOR HIGHLY POTENT IN VIVO MRNA DELIVERY

Fenton, O.S.; Kauffman, K.J.; McClellan, R.L.; Appel, E.A.; Dorkin, J.R.; Tibbitt, M.W.; Heartlein, M.W.; DeRosa, F.; Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF

INJECTABLE SELF-HEALING GLUCOSE RESPONSIVE HYDROGELS WITH PH-BASED REGULATED MECHANICAL PROPERTIES

Yesilyurt, V.; Webber, M.J.; Appel, E.A.; Godwin, C., Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF

INJECTABLE AND GLUCOSE-RESPONSIVE HYDROGELS BASED ON BORONIC ACID-GLUCOSE COMPLEXATION

Dong, Y.; Wang, W.; Veiseh, O.; Appel, E.A.; Xue, K.; Webber, M.J.; Tang, B.; Yang, X.-W.; Weir, G.; Langer, R.; Anderson, D.G.* Langmuir (2016) PDF

WATER SOLUBLE, BIODEGRADABLE AMPHIPHILIC POLYMERIC NANOPARTICLES AND THE MOLECULAR ENVIRONMENT OF HYDROPHOBIC ENCAPSULATES: CONSISTENCY BETWEEN SIMULATION AND EXPERIMENT

Miller, R.D.*; Yusoff, R.M.; Swope, W.C.; Rice, J.E.; Carr, A.C.; Parker, A.J.; Sly, J.; Appel, E.A.; Nguyen, R.; Piunova, V. Polymer (2015) PDF

FORMATION OF CUCURBIT[8]URIL-BASED SUPRAMOLECULAR HYDROGEL BEADS USING DROPLET-BASED MICROFLUIDICS

Xu, X.; Appel, E.A.; Liu, X.; Parker, R.; Scherman, O.A.; Abell, C.* Biomacromolecules (2015) PDF

EXPLOITING ELECTROSTATIC INTERACTIONS IN POLYMER-NANOPARTICLE HYDROGELS

Appel, E.A.; Tibbitt, M.W.; Greer, J.M.; Fenton, O.S.; Kreuels, K.; Anderson, D.G.; Langer, R.* ACS Macro Letters (2015) PDF

SELF-ASSEMBLED HYDROGELS UTILISING POLYMER-NANOPARTICLE INTERACTIONS

Appel, E.A.^; Tibbitt, M.W.^; Webber, M.J.; Mattix, B.A.; Veiseh, O.; Langer, R.* Nature Communications (2015) PDF

A FACILE METHOD FOR THE STAIN-FREE VISUALIZATION OF HIERARCHICAL STRUCTURES WITH ELECTRON MICROSCOPY

Williams, P.E.; Appel, E.A.; Jones, S.T.; del Barrio, J.; Lan, Y.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2015) PDF

SYNTHESIS OF CONDUCTING POLYMER-METAL NANOPARTICLE HYBRIDS VIA RAFT POLYMERIZATION

Williams, P.E.; Jones, S.T.; Walsh, Z.; Appel, E.A.; Abo-Hamed, E.K.; Scherman, O.A.* ACS Macro Letters (2015) PDF

NON-CELL-ADHESIVE SUBSTRATES FOR PRINTING OF ARRAYED BIOMATERIALS

Appel, E.A.; Larson, B.L.; Luly, K.M.; Kim, J.D.; Langer, R.* Advanced Healthcare Materials (2014) PDF

HEALABLE, STABLE AND STIFF HYDROGELS: COMBINING CONFLICTING PROPERTIES USING DYNAMIC AND SELECTIVE THREE-COMPONENT RECOGNITION WITH REINFORCING CELLULOSE NANORODS

Mckee, J.^; Appel, E.A.^; Seitsonen, J.; Kontturi, E.; Scherman, O.A.*; Ikkala, O.* Advanced Functional Materials (2014) PDF

THE CONTROL OF CARGO RELEASE FROM PHYSICALLY CROSSLINKED HYDROGELS BY CROSSLINK DYNAMICS

Appel, E.A.; Forster, R.A.; Rowland, M.J.; Scherman, O.A.* Biomaterials (2014) PDF

ACTIVATION ENERGIES CONTROL MACROSCOPIC PROPERTIES OF PHYSICALLY CROSSLINKED MATERIALS

Appel, E.A.; Forster, R.A.; Koutsiobas, A.; Toprakcioglu, C.; Scherman, O.A.* Angewandte Chemie International Edition (2014) PDF

GLUING GELS: A NANOPARTICLE SOLUTION

Appel, E.A.* and Scherman, O.A.* Nature Materials (2014) PDF

DYNAMICALLY CROSSLINKED MATERIALS VIA RECOGNITION OF AMINO ACIDS BY CUCURBIT[8]URIL

Rowland, M.J.^; Appel, E.A.^; Coulston, R.; Scherman, O.A.* Journal of Materials Chemistry B (2013) PDF

TRIGGERED INSULIN RELEASE STUDIES OF TRIPLY RESPONSIVE SUPRAMOLECULAR MICELLES

Loh, X.J.; Tsai, M.-H.; del Barrio, J.; Appel, E.A.; Scherman, O.A.* Polymer Chemistry (2012) PDF

TRIPLY TRIGGERED DOXORUBICIN RELEASE FROM SUPRAMOLECULAR NANOCONTAINERS

Loh, X.J.; del Barrio, J.; Toh, P.P.C.; Lee, T.-C.; Jiao, D.; Rauwald, U.; Appel, E.A.; Scherman, O.A.* Biomacromolecules (2012) PDF

HIGH MOLECULAR WEIGHT POLYACRYLAMIDES BY ATRP: ENABLING ADVANCEMENTS IN WATER-BASED APPLICATIONS

Appel, E.A.; del Barrio, J.; Loh, X.J.; Dyson, J.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2012) PDF

BIODEGRADABLE NANOGEL STAR POLYMERS VIA ORGANOCATALYTIC ROP

Appel, E.A.; Lee, V.Y.; Nguyen, T.T.; McNeil, M.; Hedrick, J.L.; Miller, R.D.*; Sly, J.* Chemical Communications (2012) PDF

SUPRAMOLECULAR POLYMERIC HYDROGELS

Appel, E.A.; del Barrio, J.; Loh, X.J.; Scherman, O.A.* Chemical Society Reviews (2012) PDF

ENHANCED STABILITY AND ACTIVITY OF TEMOZOLOMIDE IN PRIMARY GBM CELLS WITH CUCURBIT[n]URIL

Appel, E.A.^; Rowland, M.J.^; Loh, X.J.; Heywood, R.M.; Watts, C.; Scherman, O.A.* Chemical Communications (2012) PDF

SUSTAINED RELEASE OF PROTEINS FROM A HIGH-WATER-CONTENT SUPRAMOLECULAR POLYMERIC HYDROGEL

Appel, E.A.; Loh, X.J.; Jones, S.T.; Dreiss, C.A.; Scherman, O.A.* Biomaterials (2012) PDF

ULTRAHIGH-WATER-CONTENT HYDROGELS FROM RENEWABLE RESOURCES EXHIBITING MULTI-STIMULI RESPONSIVENESS

Appel, E.A.; Loh, X.J.; Jones, S.T.; Biedermann, F.; Dreiss, C.A.; Scherman, O.A.* Journal of the American Chemical Society (2012) PDF

METASTABLE SINGLE-CHAIN POLYMER NANOPARTICLES PREPARED BY DYNAMIC CROSSLINKING WITH NOR-SECO-CUCURBIT[10]URIL

Appel, E.A.; Dyson, J.; del Barrio, J.; Isaacs, L.; Scherman, O.A.* Chemical Science (2012) PDF

FORMATION OF SINGLE-CHAIN POLYMER NANOPARTICLES IN WATER THROUGH HOST-GUEST INTERACTIONS

Appel, E.A.; Dyson, J.; del Barrio, J.; Walsh, Z.; Scherman, O.A.* Angewandte Chemie International Edition (2012) PDF
- highlighted as a ''Hot Paper'' by the editors of Angew. Chem. Int. Ed. 

POST-POLYMERIZATION MODIFICATION OF HYDROXYL-FUNCTIONALIZED POLYMERS WITH ISOCYANATES

Biedermann, F.; Appel, E.A.; del Barrio, J.; Gruendling, T.; Barner-Kowollik, C.; Scherman, O.A.* Macromolecules (2011) PDF

SUPRAMOLECULAR GOLD NANOPARTICLE-POLYMER COMPOSITES FORMED IN WATER WITH CUCURBIT[8]URIL

Coulston, R.J.; Jones, S.T.; Lee, T.-C.; Appel, E.A.; Scherman, O.A.* Chemical Communications (2011) PDF

SUPRAMOLECULAR CROSS-LINKED NETWORKS VIA HOST-GUEST COMPLEXATION WITH CUCURBIT[8]URIL

Appel, E.A.; Biedermann, F.; Rauwald, U.; Zayed, J.M.; Scherman, O.A.* Journal of the American Chemical Society (2010) PDF
- highlighted in ''Hosting Hydrogel Formation,'' Synfacts (2010)

HIERARCHICAL SUPERMOLECULAR STRUCTURES FOR SUSTAINED DRUG RELEASE

Tan, J.P.K.; Kim, S.H.; Nederberg, F.; Appel, E.A.; Waymouth, R.M.; Zhang, Y.; Hedrick, J.L.*; Yang, Y.Y.* Small (2009) PDF

SIMPLE APPROACH TO STABILIZED MICELLES EMPLOYING MIKTOARM TERPOLYMERS AND STEREOCOMPLEXES WITH APPLICATION IN PACLITAXEL DELIVERY

Nederberg, F.; Appel, E.A.; Tan, J.P.K.; Kim, S.H.; Fukushima, K.; Sly, J.; Miller, R.D.; Waymouth, R. M.*; Yang, Y. Y.*; Hedrick, J. L.* Biomacromolecules (2009) PDF