Supramolecular (Bio)Materials

GLASSY SURFACTANTS ENABLE ULTRA-HIGH CONCENTRATION BIOLOGIC THERAPEUTICS

Jons, C.K.^; Prossnitz, A.N.^; Eckman, N.; Dong, C.; Appel, E.A.*

PREVENTING PERITENDENOUS ADHESIONS USING LUBRICIOUS SUPRAMOLECULAR HYDROGELS

Meany, E.L.^; Williams, C.M.^; Song, Y.E.; Doulames, V.M.; Bailey, S.J.; Williams, S.C.; Jons, C.K.; Fox, P.M.*; Appel, E.A.*

EVOLVING TRANSPORT PROPERTIES OF DYNAMIC HYDROGELS ENABLE SELF-TUNING OF SHORT- AND LONG-TERM CARGO DELIVERY

Sen, S.; Dong, C.; Jons, C.K.; Song, Y.E.; Prossnitz, A.N.; Appel, E.A.*

SPATIALLY TUNED LOCALIZATION OF INTERLEUKINS AND OX40 AGONISTS ENHANCES SYNERGISTIC ANTI-TUMOR IMMUNITY

Klich, J.H.; Nejatfard, A.; Meany, E.L.; Ou, B.S.; Baillet, J.; Appel, E.A.*

ENGINEERING SUSTAINED-RELEASE BROADLY NEUTRALIZING ANTIBODY FORMULATIONS

Jons, C.K.; Kasse, C.M.; Mayer, B.T.; Hyrien, O.; Sen, S.; Meany, E.L.; d’Aquino, A.I.; Ganesh, P.; Eckman, N.; Dong, C.; Yan, J.; Nguyen, L.T.; Doulames, V.M.; Song, Y.E.; Saouaf, O.M.; Williams, C.M.; Williams, S.C.; Paredes, J.; Raghavan, R.; Palomares, M.; Alpert, M.; Yates, N.L.; Tomaras, G.D.; Seaman, M.S.; Farzan, M.; Appel, E.A.*

LONG-ACTING HYDROGEL-BASED DEPOT FORMULATIONS OF TIRZEPATIDE AND SEMAGLUTIDE FOR THE MANAGEMENT OF TYPE 2 DIABETES AND WEIGHT

d'Aquino, A.I.^; Dong, C.^; Nguyen, L.T.; Yan, J.; Jons, C.K.; Saouaf, O.M.; Song, Y.E.; Eckman, N.; Kapasi, S.; Williams, C.M.; Doulames, V.; Sen, S.; Manna, M.K.; Alakesh, A.; Lu, K.; Hall, I.; Appel, E.A.*

A TRANSIENT IMMUNOSTIMULATORY NICHE SYNERGIZES ADOPTIVE AND ENDOGENOUS IMMUNITY FOR ENHANCED TUMOR CONTROL

Nejatfard, A.; Klich, J.H.; Eckman, N.; Bailey, S.J.; Gillard, K.; Ramos Mejia, D.; Ou, B.S.; Yan, J.; Hickey, J.W.; Appel, E.A.*

SAPONIN NANOPARTICLE ADJUVANTS INCORPORATING TOLL-LIKE RECEPTOR AGONISTS IMPROVE VACCINE IMMUNOMODULATION

Ou, B.S.^; Baillet, J.^; Filsinger Interrante, M.V.; Adamska, J.S.; Zhou, X.; Saouaf, O.A.; Yan, J.; Klich, J.H.; Jons, C.K.; Meany, E.L.; Valdez, A.; Carter, L.; Pulendran, B.; King, N.P.; Appel, E.A.* Science Advances (2024) PDF

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WATER-ENHANCING GELS EXHIBITING HEAT-ACTIVATED FORMATION OF SILICA AEROGELS FOR PROTECTION OF CRITICAL INFRASTRUCTURE DURING CATASTROPHIC WILDFIRE

Dong, C.; d'Aquino, A.I.; Sen, S.; Hall, I.A.; Yu, A.C.; Acosta, J.D.; Appel, E.A.* Advanced Materials (2024) PDF

Check out some cool burn videos of our hydrogel technology compared to commercial products!

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NANOPARTICLE-CONJUGATED TLR9 AGONISTS IMPROVE THE POTENCY, DURABILITY, AND BREADTH OF COVID-19 VACCINES

Ou, B.S.^; Baillet, J.^; Picece, V.C.T.M.^; Gale, E.C.; Powell, A.E.; Saouaf, O.M.; Yan, J.; Nejatfard, A.; Lopez Hernandez, H.; Appel, E.A.* ACS Nano (2024) PDF

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BIOMATERIALS TO ENHANCE ADOPTIVE CELL THERAPY

Eckman, N.^; Nejatfard, A.^; Cavet, R.; Grosskopf, A.K.*; Appel, E.A.* Nature Reviews Bioengineering (2024) PDF

A cGAMP-CONTAINING HYDROGEL FOR PROLONGED SARS-COV-2 RBD SUBUNIT VACCINE EXPOSURE INDUCES A BROAD AND POTENT HUMORAL RESPONSE

Bohnert, V.^; Gale, E.C.^; Lahey, L.J.^; Yan, J.; Powell, A.E.; Ou, B.S.; Carozza, J.A.; Li, L.*; Appel, E.A.* Advanced NanoBiomed Research (2024) PDF

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BIOMIMETIC NON-ERGODIC AGING BY DYNAMIC-TO-COVALENT TRANSITIONS IN PHYSICAL HYDROGELS

Sen, S.; Dong, C.; d’Aquino, A.I.; Yu, A.C.; Appel, E.A.* ACS Applied Materials & Interfaces (2024) PDF

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ELECTROCHEMICALLY MUTABLE SOFT METASURFACES

Doshi, S.; Ji, A.; Mahdi, A.I.; Keene, S.T.; Selvin, S.; Lalanne, P.; Appel, E.A.; Melosh, N.A.*; Brongersma, M.L.* Nature Materials (2024) PDF

VIRAL VECTOR ELUTING LENSES FOR SINGLE-STEP TARGETED EXPRESSION OF GENETICALLY-ENCODED ACTIVITY SENSORS FOR IN VIVO MICROENDOSCOPIC CALCIUM IMAGING

Jons, C; Cheng, D.; Dong, C.; Meany, E.; Nassi, J.*; Appel, E.A.* Macromolecular Biosciences (2024) PDF

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LABEL-FREE COMPOSITION ANALYSIS OF SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS BY REVERSED-PHASE LIQUID CHROMATOGRAPHY COUPLED WITH A CHARGED AEROSOL DETECTOR

Tang, S.^; Pederson, Z.^; Meany, E.L.; Yen, C.-W.; Swansiger, A.K.; Prell, J.S.; Chen, B.; Grosskopf, A.K.; Eckman, N.; Jiang, G.; Baillet, J.; Pellett, J.D.; Appel, E.A.* Analytical Chem (2024) PDF

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COMPOSITE GELS DESIGNED TO STICK TO BIOLOGICAL TISSUES

Bailey, S.J.; Appel, E.A.* Nature (2024) PDF

Check out the original article in Nature Chem Eng by Prof. Bozhi Tian and coworkers.

ENGINEERING MATERIALS FOR IMPROVED CULTURE OF HUMAN MESENCHYMAL STEM CELLS

Stapleton, L.M.; Chan, D.; Hartmann, F.J.; Bendall, S.C.; Appel, E.A.* PDF

This work was peer reviewed but never published because of COVID-related challenges.

AN ATLAS OF THE MECHANICAL PROPERTIES OF SOFT ORGANS IN MICE AS MEASURED BY INTERFEROMETRY-BASED NANOINDENTATION

Axpe, E.; Chan, D.; Efremov, Y.M.; Correa, S.; Grosskopf, A.K.; Appel, E.A.* PDF

This work was peer reviewed but never published because of COVID-related challenges.

TUNING HYDROGEL SURFACE WETTING PROPERTIES VIA BIOMIMETIC IMPRINTING

Picece, V.C.T.M.; Chan, D.; Axpe, E.; Cheong, J.C.; Appel, E.A.* PDF

This work was peer reviewed but never published because of COVID-related challenges.

SUSTAINED DELIVERY OF GLP-1 RECEPTOR AGONISTS FROM INJECTABLE BIOMIMETIC HYDROGELS IMPROVES TREATMENT OF DIABETES

d’Aquino, A.I.; Maikawa, C.L.; Nguyen, L.T.; Lu, K.; Hall, I.A.; Prossnitz, A.N.; Chang, E.; Baker, S.W.; Kasse, C.I.; Jons, C.K.; Yan, J.; Hovgaard, L.; Steensgaard, D.B.; Andersen, H.B.; Simonsen, L.; Appel, E.A.* Cell Reports Medicine (2023) PDF

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BROAD AND DURABLE HUMORAL RESPONSES FOLLOWING SINGLE HYDROGEL IMMUNIZATION OF SARS-COV-2 SUBUNIT VACCINES

Ou, B.S.; Saouaf, O.M.; Yan, J.; Bruun, T.U.J.; Baillet, J.; King, N.P.; Appel, E.A.* Advanced Healthcare Materials (2023) PDF

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A REGIMEN COMPRESSION STRATEGY FOR COMMERCIAL VACCINES LEVERAGING AN INJECTABLE HYDROGEL DEPOT TECHNOLOGY FOR SUSTAINED VACCINE EXPOSURE

Yan, J.; Ou, B.S.; Saouaf, O.M.; Meany, E.L.; Eckman, N.; Appel, E.A.* Advanced Therapeutics (2023) PDF

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SUBCUTANEOUS DELIVERY OF AN ANTIBODY AGAINST SARS-COV-2 FROM A SUPRAMOLECULAR HYDROGEL DEPOT

Kasse, C.M.; Yu, A.C.; Powell, A.C.; Roth, G.A.; Liong, C.S.; Jons, C.K.; Buahin, A.; Maikawa, C.L.; Youssef, S.; Glanville, J.E.; Appel, E.A.* Biomaterials Science (2023) PDF

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POLYACRYLAMIDE-BASED HYDROGEL COATINGS IMPROVE BIOCOMPATIBILITY OF IMPLANTED PUMP DEVICES

Chan, D.; Maikawa, C.L.; d’Aquino, A.I.; Raghavan, S.S.; Troxell, M.L.; Appel, E.A.* J. Biomed. Mater. Res. Part A. (2023) PDF

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MICROFLUIDIC ENCAPSULATION OF PHOTOSYNTHETIC CYANOBACTERIA IN HYDROGEL MICROPARTICLES AUGMENTS OXYGEN DELIVERY TO RESCUE ISCHEMIC MYOCARDIUM

Stapleton, L.M.; Farry, J.M.; Zhu, Y.; Lucian, H.J.; Wang, H.; Paulsen, M.J.; Totherow, K.P.; Roth, G.A.; Brower, K.K.; Fordyce, P.M.; Appel, E.A.; Woo, Y.J.* J. Biosci. Bioeng. (2023) PDF

INJECTABLE HYDROGELS FOR IMMUNE MODULATION

Saouaf, O.M.; d’Aquino, A.I.; Grosskopf, A.K; Appel, E.A.* Biomedical Nanotechnology: Methods and Protocols (2023)

ANGIOGENIC STEM CELL DELIVERY PLATFORM TO AUGMENT POST-INFARCTION NEOVASCULATURE AND REVERSE VENTRICULAR REMODELING

Shin, H.S.; Thakore, A.; Tada, Y.; Pedroza, A.J.; Ikeda, G.; Chen, I.C.; Chan, D.; Jaatinen, K.J.; Yajima, S.; Pfrender, E.M.; Kawamura, M.; Yang, P.C.; Wu, J.C.; Appel, E.A.; Fischbein, M.P.; Woo, Y.J.; Shudo, Y.* Scientific Reports (2023) PDF

DELIVERY OF CAR-T CELLS IN A TRANSIENT INJECTABLE STIMULATORY NICHE IMPROVES TREATMENT OF SOLID TUMORS

Grosskopf, A.K.^; Labanieh, L.^; Klysz, D.D.; Roth, G.A.; Xu, P.; Adebowale, O.; Gale, E.C.; Jons, C.K.; Klich, J.H.; Yan, J.; Maikawa, C.L.; Correa, S.; Ou, B.S.; d’Aquino, A.I.; Cochran, J.R.; Chaudhuri, O.; Mackall, C.L.*; Appel, E.A.* Science Advances (2022) PDF

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DESIGNING SPATIAL AND TEMPORAL CONTROL OF VACCINE RESPONSES

Roth, G.A.; Picece, V.T.M.; Ou, B.S.; Luo, W.; Pulendran, B.; Appel, E.A.* Nature Reviews Materials (2022) PDF

INJECTABLE LIPOSOME BASED SUPRAMOLECULAR HYDROGELS FOR THE PROGRAMMABLE RELEASE OF MULTIPLE PROTEIN DRUGS

Correa, S.^; Grosskopf, A.K.^; Klich, J.H.; Lopez Hernandez, H.; Appel, E.A.* Matter - Cell Press (2022) PDF

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COMBINATORIAL POLYACRYLAMIDE HYDROGELS FOR PREVENTING BIOFOULING ON IMPLANTABLE BIOSENSORS

Chan, D.^; Chien, J.-C.^; Axpe, E.; Blankemeier, L.; Baker, S.W.; Swaminathan, S.; Piunova, V.A.; Zubarev, D.Y.; Maikawa, C.L.; Grosskopf, A.K.; Mann, J.L.; Soh, H.T.*; Appel, E.A.* Advanced Materials (2022) PDF

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YIELD-STRESS AND CREEP CONTROL DEPOT FORMATION AND PERSISTENCE OF INJECTABLE HYDROGELS FOLLOWING SUBCUTANEOUS ADMINISTRATION

Jons, C.K.; Grosskopf, A.K.; Baillet, J.; Yan, J.; Klich, J.H.; Appel, E.A.* Advanced Functional Materials (2022) PDF

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INJECTABLE NANOPARTICLE-BASED HYDROGELS ENABLE THE SAFE AND EFFECTIVE DEPLOYMENT OF IMMUNOSTIMULATORY CD40 AGONIST ANTIBODIES

Correa, S.; Meany, E.L.; Gale, E.C.; Klich, J.H.; Saouaf, O.M.; Mayer, A.T.; Xian, Z.; Liong, C.; Brown, R.A.; Maikawa, C.L.; Grosskopf, A.K.; Mann, J.L.; Idoyaga, J.; Appel, E.A.* Advanced Science (2022) PDF

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REAL-TIME MONITORING OF DRUG PHARMACOKINETICS WITHIN TUMOR TISSUE IN LIVE ANIMALS

Seo, J.-W.^; Fu, K.^; Correa, S.; Eisenstein, M.; Appel, E.A.*; Soh, H.T.* Science Advances (2022) PDF

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EXTREME EXTENSIBILITY IN PHYSICALLY CROSSLINKED NANOCOMPOSITE HYDROGELS LEVERAGING DYNAMIC POLYMER-NANOPARTICLE INTERACTIONS

Grosskopf, A.K.; Mann, J.L; Baillet, J.; Lopez Hernandez, H.; Autzen, A.A.A.; Yu, A.C.; Appel, E.A.* Macromolecules (2022) PDF

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SUSTAINED DELIVERY APPROACHES TO IMPROVING ADAPTIVE IMMUNE RESPONSES

Ou, B.S.^; Saouaf, O.M.^; Baillet, J.; Appel, E.A.* Advanced Drug Delivery Reviews (2022) PDF

INJECTABLE POLYMER-NANOPARTICLE HYDROGEL FOR THE SUSTAINED INTRAVITREAL DELIVERY OF BIMATOPROST

Meany, E.L.^; Andaya, R.^; Tang, S.; Kasse, C.M.; Fuji, R.N.; Grosskopf, A.K.; d’Aquino, A.I.; Bartoe, J.T.; Ybarra, R.; Shelton, A.; Pederson, Z.; Hu, C.; Leung, D.; Nagapudi, K.; Ubhayakar, S.; Yen, C.W.*; Appel, E.A.* Advanced Therapeutics (2022) PDF

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STABLE HIGH-CONCENTRATION MONOCLONAL ANTIBODY FORMULATIONS ENABLED BY AN AMPHIPHILIC COPOLYMER EXCIPIENT

Klich, J.H.^; Kasse, C.M.^; Mann, J.L.; Huang, Y.; d’Aquino, A.I.; Grosskopf, A.K.; Baillet, J.; Fuller, G.G.; Appel, E.A.* Advanced Therapeutics (2022) PDF

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FORMULATION EXCIPIENTS AND THEIR ROLE IN INSULIN STABILITY AND ASSOCIATION STATE IN FORMULATION

Maikawa, C.L.; Nguyen, L.T.; Mann, J.L.; Appel, E.A.* Pharmaceutical Research (2022) PDF

MULTIMERIZATION OF EBOLA GPMUCIN ON PROTEIN NANOPARTICLE VACCINES HAS MINIMAL EFFECT ON ELICITATION OF NEUTRALIZING ANTIBODIES

Powell, A.E.; Xu, D.; Roth, G.A.; Zhang, K.; Chiu, W.; Appel, E.A.; Kim, P.S.* Frontiers in Immunology (2022) PDF

PNP HYDROGEL PREVENTS SYMBLEPHARA FORMATION IN MICE AFTER OCULAR ALKALI INJURY

Swarup, A.; Grosskopf, A.K.; Stapleton, L.M.; Subramanium, V.R.; Li, B.; Weissman, I.L.; Appel, E.A.; Wu, A.Y.* Translational Vision Science & Technology (2022) PDF

THE LIVING INTERFACE BETWEEN SYNTHETIC BIOLOGY AND BIOMATERIAL DESIGN

Liu, A.P.*; Appel, E.A.; Ashby, P.D.; Baker, B.M.; Franco, E.; Gu, L.; Haynes, K.; Joshi, N.S.; Kloxin, A.M.; Kouwer, P.H.J.; Mittal, J.; Morsut, L.; Noireaux, V.; Parekh, S.; Schulman, R.; Tang, S.K.Y.; Valentine, M.T.; Vega, S.L.; Weber, W.; Stephanopoulos, N.; Chaudhuri, O.* Nature Materials (2022) PDF

INJECTABLE HYDROGELS FOR SUSTAINED CO-DELIVERY OF SUBUNIT VACCINES ENHANCE HUMORAL IMMUNITY

Roth, G.A.; Gale, E.C.; Alcantara Herandez, M.; Luo, W.; Axpe, E.; Verma, R.; Yin, Q.; Yu, A.C.; Lopez Hernandez, H.; Maikawa, C.L.; Smith, A.A.A.; Davis, M.M.; Pulendran, B.; Idoyaga, I.; Appel, E.A.* ACS Central Science (2020) PDF

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AN ULTRAFAST INSULIN FORMULATION ENABLED BY HIGH-THROUGHPUT SCREENING OF ENGINEERED POLYMERIC EXCIPIENTS

Mann, J.L.^; Maikawa, C.L.^; Smith, A.A.A.; Grosskopf, A.K.; Baker, S.W.; Roth, G.A.; Meis, C.M.; Gale, E.C.; Liong, C.S.; Correa, S.; Chan, D.; Stapleton, L.S.; Yu, A.C.; Muir, B.; Howard, S.; Postma, A.; Appel, E.A.* Science Translational Medicine (2020) PDF

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A CO-FORMULATION OF SUPRAMOLECULARLY STABILIZED INSULIN AND PRAMLINTIDE ENHANCES MEALTIME GLUCAGON SUPPRESSION IN DIABETIC PIGS

Maikawa, C.L.; Smith, A.A.A.; Zou, L.; Roth, G.A.; Gale, E.C.; Stapleton, L.M.; Baker, S.W.; Mann, J.L.; Yu, A.C.; Correa, S.; Grosskopf, A.K.; Liong, C.S.; Meis, C.M.; Chan, D.; Troxell, M.; Maahs, D.M.; Buckingham, B.A.; Webber, M.J.; Appel, E.A.* Nature Biomedical Engineering (2020) PDF

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A FLUORESCENCE SANDWICH IMMUNOASSAY FOR THE REAL-TIME CONTINUOUS DETECTION OF GLUCOSE AND INSULIN IN LIVE ANIMALS

Poudineh, M.^; Maikawa, C.L.^; Ma, E.Y.; Pan, J.; Mamerow, D.; Hang, Y.; Baker, S.W.; Beirami, A.; Yoshikawa, A.; Eisenstein, M.; Kim, S.; Vuckovic, J.; Appel, E.A.*; Soh, H.T.* Nature Biomedical Engineering (2020) PDF

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NANOPARTICLES PRESENTING POTENT TLR7/8 AGONISTS ENHANCE ANTI-PD-L1 IMMUNOTHERAPY IN CANCER TREATMENT

Smith, A.A.A.^; Gale, E.C.^; Roth, G.A.; Maikawa, C.L.; Correa, S.; Yu, A.C.; Appel, E.A.* Biomacromolecules (2020) PDF

SELF-ASSEMBLED, DILUTION-RESPONSIVE HYDROGELS FOR ENHANCED THERMAL STABILITY OF INSULIN BIOPHARMACEUTICALS

Meis, C.M.; Salzman, E.E.; Maikawa, C.L.; Smith, A.A.A.; Mann, J.L.; Grosskopf, A.K.; Appel, E.A.* ACS Biomaterials Science & Engineering (2020) PDF

LIPID NANODISCS VIA ORDERED COPOLYMERS

Smith, A.A.A.^; Autzen, H.E.^; Faust, B; Mann, J.L.; Muir, B.W.; Howard, S.; Postma, A.; Spakowitz, A.J.; Cheng, Y.*; Appel, E.A.* Chem - Cell Press (2020) PDF

A QUANTITATIVE DESCRIPTION FOR DESIGNING THE EXTRUDABILITY OF SHEAR-THINNING PHYSICAL HYDROGELS

Lopez Hernandez, H.; Souza, J.W.; Appel, E.A.* Macromolecular Bioscience (2020) PDF

STRUCTURAL CONSIDERATIONS FOR PHYSICAL HYDROGELS BASED ON POLYMER-NANOPARTICLE INTERACTIONS

Yu, A.C.; Smith, A.A.A.; Appel, E.A.* Molecular Systems Design & Engineering (2020) PDF

SITE-SELECTIVE MODIFICATION OF PROTEINS USING CUCURBIT[7]URIL AS SUPRAMOLECULAR PROTECTION FOR N-TERMINAL AROMATIC AMINO ACIDS

Smith, A.A.A.; Maikawa, C.L.; Roth, G.A.; Appel, E.A.* Organic & Biomolecular Chemistry (2020) PDF

HIGHLY-BRANCHED POLYDIMETHYLACRYLMIDE COPOLYMERS AS FUNCTIONAL BIOMATERIALS

Mann, J.L.; Grosskopf, A.K.; Smith, A.A.A.; Appel, E.A.* Biomacromolecules (2020) PDF

ENGINEERED BIOMATERIALS FOR HEART DISEASE

Stapleton, L.M.; Zhu, Y.; Woo, J.Y.; Appel, E.A.* Current Opinion in Biotechnology (2020) PDF

WILL THE PANDEMIC MAKE THE WEST MORE VULNERABLE TO WILDFIRES?

Field, C.B.*; Appel, E.A.* New York Times (2020) PDF

MULTI-PHASE CATHETER-INJECTABLE HYDROGEL ENABLES DUAL-STAGE PROTEIN-ENGINEERED CYTOKINE RELEASE TO MITIGATE ADVERSE LEFT VENTRICULAR REMODELING FOLLOWING MYOCARDIAL INFARCTION IN A SMALL ANIMAL MODEL AND A LARGE ANIMAL MODEL

Steele, A.N.; Paulsen, M.J.; Wang, H.; Stapleton, L.M.; Lucian, H.J.; Eskandari, A.; Hironaka, C.E.; Farry, J.M.; Baker, S.W.; Thakore, A.D.; Jaatinen, K.J.; Tada, Y.; Hollander, M.J.; Williams, K.M.; Seymour, A.J.; Totherow, K.; Yu, A.C.; Cochran, J.R.; Appel, E.A.; Woo, Y.J.* Cytokine (2020) PDF

A HUMAN MISSION TO MARS: PREDICTING THE BONE MINERAL DENSITY LOSS OF ASTRONAUTS

Axpe, E.; Chan, D.; Abegaz, M.F.; Schreurs, A.-S.; Alwood, J.S.; Globus, R.K; Appel, E.A.* PLOS One (2020) PDF

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TOWARDS BRAIN-TISSUE-LIKE BIOMATERIALS

Axpe, E.; Orive, G.; Franze, K.; Appel, E.A.* Nature Communications (2020) PDF

THE COVID-19 LOCKDOWNS: A WINDOW INTO THE EARTH SYSTEM

Diffenbaugh, N.S.*; Field, C.B.; Appel, E.A.; Baldocchi, D.D.; Burke, M.; Burney, J.A.; Davis, S.J.; Fiore, A.M.; Fletcher, S.M.; Hertel, T.W.; Horton, D.E.; Hsiang, S.M.; Jackson, R.B.; Jin, X.; Levi, M.; Lobell, D.B.; McKinley, G.A.; Moore, F.C.; Montgomery, A.; Nadeau, K.C.; Pataki, D.E.; Randerson, J.T.; Reichstein, M.; Schnell, J.L.; Seneviratne, S.L.; Singh, D.; Steiner, A.L.; Wong-Parodi, G. Nature Reviews Earth & Environment (2020) PDF

MRBLES 2.0: HIGH-THROUGHPUT GENERATION OF CHEMICALLY FUNCTIONALIZED SPECTRALLY AND MAGNETICALLY ENCODED HYDROGEL BEADS USING A SIMPLE SINGLE-LAYER MICROFLUIDIC DEVICE

Feng, Y.; White, A.K.; Hein, J.B.; Appel, E.A.; Fordyce, P.M.* Microsystems & Nanoengineering (2020) PDF

MIXED REVERSIBLE COVALENT CROSSLINK KINETICS ENABLE PRECISE, HIERARCHICAL MECHANICAL TUNING OF HYDROGEL NETWORKS

Yesilyurt, V.^; Ayoob, A.M.^; Appel, E.A.; Borenstein, J.T.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF

SINGLE-CHAIN POLYMERIC NANOCARRIERS: A PLATFORM FOR DETERMINING STRUCTURE-FUNCTION CORRELATIONS IN THE DELIVERY OF MOLECULAR CARGO

Chan, D.; Yu, A.; Appel, E.A.* Biomacromolecules (2017) PDF

SYNTHESIS AND BIOLOGICAL EVALUATION OF IONIZABLE LIPID MATERIALS FOR THE IN VIVO DELIVERY OF MESSENGER RNA TO B LYMPHOCYTES

Fenton, O.S.; Kauffman, K.J.; Kaczmarek, J.C.; McClellan, R.L.; Jhunjhunwala, S.; Tibbitt, M.W.; Zeng, M.D.; Appel, E.A.; Dorkin, J.R.; Mir, F.F.; Yang, J.H.; Oberli, M.A.; Heartlein, M.W.; DeRosa, R.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF

DECOUPLED ASSOCIATIVE AND DISSOCIATIVE PROCESSES IN HIGHLY DYNAMIC HOST-GUEST COMPLEXES

Appel, E.A.*; Biedermann, F.*; Hoogland, D.; del Barrio, J.; Driscoll, M.D.; Hay, S.; Wales, D.J.; Scherman, O.A.* Journal of the American Chemical Society (2017) PDF

DISTINGUISHING RELAXATION DYNAMICS IN TRANSIENTLY CROSSLINKED POLYMERIC NETWORKS

Tan, C.S.Y.; Agmon, G.; Liu, J.; Hoogland, D.; Janecek, E.-R.; Appel, E.A.*; Scherman, O.A.* Polymer Chemistry (2017) PDF

MECHANISTIC UNDERSTANDING OF IN VIVO PROTEIN CORONA FORMATION ON POLYMERIC NANOPARTICLES AND IMPACT ON PHARMACOKINETICS

Bertrand, N.; Grenier, P.; Mahmoudi, M.; Lima, E.; Appel, E.A.; Dormont, F.; Lim, J.-M.; Karnik, R.; Langer, R.; Farokhzad, O.* Nature Communications (2017) PDF

SUPRAMOLECULAR POLYMERIC BIOMATERIALS

Mann, J.L.^; Yu, A.C.^; Agmon, G.; Appel, E.A.* Biomaterials Science (2017) PDF

ENGINEERING THE MECHANICAL PROPERTIES OF POLYMER NETWORKS WITH PRECISE DOPING OF PRIMARY DEFECTS

Chan, D.; Ding, Y.; Dauskardt, R.H.; Appel, E.A.* ACS Applied Materials and Interfaces (2017) PDF

SCALABLE MANUFACTURING OF BIOMIMETIC MOLDABLE HYDROGELS FOR INDUSTRIAL APPLICATIONS

Yu, A.C.; Chen, H.; Chan, D.; Agmon, G.; Stapleton, L.M.; Sevit, A.M.; Tibbitt, M.W.; Acosta, J.D.; Zhang, T.; Franzia, P.W.; Langer, R.; Appel, E.A.* Proceedings of the National Academy of Sciences (2016) PDF

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SUPRAMOLECULAR BIOMATERIALS

Webber, M.J.^; Appel, E.A.^; Meijer, E.W.; Langer, R.* Nature Materials (2016) PDF

SUPRAMOLECULAR PEGYLATION OF BIOPHARMACEUTICALS

Webber, M.J.^; Appel, E.A.^; Vinciguerra, B.; Thapa, L.S.; Cortinas, A.B.; Jhunjhunwala, S.; Isaacs, L.*; Langer, R.*; Anderson, D.G.* Proceedings of the National Academy of Sciences (2016) PDF

BIOINSPIRED ALKENYL AMINO ALCOHOL IONIZABLE LIPID MATERIALS FOR HIGHLY POTENT IN VIVO MRNA DELIVERY

Fenton, O.S.; Kauffman, K.J.; McClellan, R.L.; Appel, E.A.; Dorkin, J.R.; Tibbitt, M.W.; Heartlein, M.W.; DeRosa, F.; Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF

INJECTABLE SELF-HEALING GLUCOSE RESPONSIVE HYDROGELS WITH PH-BASED REGULATED MECHANICAL PROPERTIES

Yesilyurt, V.; Webber, M.J.; Appel, E.A.; Godwin, C., Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF

INJECTABLE AND GLUCOSE-RESPONSIVE HYDROGELS BASED ON BORONIC ACID-GLUCOSE COMPLEXATION

Dong, Y.; Wang, W.; Veiseh, O.; Appel, E.A.; Xue, K.; Webber, M.J.; Tang, B.; Yang, X.-W.; Weir, G.; Langer, R.; Anderson, D.G.* Langmuir (2016) PDF

WATER SOLUBLE, BIODEGRADABLE AMPHIPHILIC POLYMERIC NANOPARTICLES AND THE MOLECULAR ENVIRONMENT OF HYDROPHOBIC ENCAPSULATES: CONSISTENCY BETWEEN SIMULATION AND EXPERIMENT

Miller, R.D.*; Yusoff, R.M.; Swope, W.C.; Rice, J.E.; Carr, A.C.; Parker, A.J.; Sly, J.; Appel, E.A.; Nguyen, R.; Piunova, V. Polymer (2015) PDF

FORMATION OF CUCURBIT[8]URIL-BASED SUPRAMOLECULAR HYDROGEL BEADS USING DROPLET-BASED MICROFLUIDICS

Xu, X.; Appel, E.A.; Liu, X.; Parker, R.; Scherman, O.A.; Abell, C.* Biomacromolecules (2015) PDF

EXPLOITING ELECTROSTATIC INTERACTIONS IN POLYMER-NANOPARTICLE HYDROGELS

Appel, E.A.; Tibbitt, M.W.; Greer, J.M.; Fenton, O.S.; Kreuels, K.; Anderson, D.G.; Langer, R.* ACS Macro Letters (2015) PDF

SELF-ASSEMBLED HYDROGELS UTILISING POLYMER-NANOPARTICLE INTERACTIONS

Appel, E.A.^; Tibbitt, M.W.^; Webber, M.J.; Mattix, B.A.; Veiseh, O.; Langer, R.* Nature Communications (2015) PDF

A FACILE METHOD FOR THE STAIN-FREE VISUALIZATION OF HIERARCHICAL STRUCTURES WITH ELECTRON MICROSCOPY

Williams, P.E.; Appel, E.A.; Jones, S.T.; del Barrio, J.; Lan, Y.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2015) PDF

SYNTHESIS OF CONDUCTING POLYMER-METAL NANOPARTICLE HYBRIDS VIA RAFT POLYMERIZATION

Williams, P.E.; Jones, S.T.; Walsh, Z.; Appel, E.A.; Abo-Hamed, E.K.; Scherman, O.A.* ACS Macro Letters (2015) PDF

NON-CELL-ADHESIVE SUBSTRATES FOR PRINTING OF ARRAYED BIOMATERIALS

Appel, E.A.; Larson, B.L.; Luly, K.M.; Kim, J.D.; Langer, R.* Advanced Healthcare Materials (2014) PDF

HEALABLE, STABLE AND STIFF HYDROGELS: COMBINING CONFLICTING PROPERTIES USING DYNAMIC AND SELECTIVE THREE-COMPONENT RECOGNITION WITH REINFORCING CELLULOSE NANORODS

Mckee, J.^; Appel, E.A.^; Seitsonen, J.; Kontturi, E.; Scherman, O.A.*; Ikkala, O.* Advanced Functional Materials (2014) PDF

THE CONTROL OF CARGO RELEASE FROM PHYSICALLY CROSSLINKED HYDROGELS BY CROSSLINK DYNAMICS

Appel, E.A.; Forster, R.A.; Rowland, M.J.; Scherman, O.A.* Biomaterials (2014) PDF

ACTIVATION ENERGIES CONTROL MACROSCOPIC PROPERTIES OF PHYSICALLY CROSSLINKED MATERIALS

Appel, E.A.; Forster, R.A.; Koutsiobas, A.; Toprakcioglu, C.; Scherman, O.A.* Angewandte Chemie International Edition (2014) PDF

GLUING GELS: A NANOPARTICLE SOLUTION

Appel, E.A.* and Scherman, O.A.* Nature Materials (2014) PDF

DYNAMICALLY CROSSLINKED MATERIALS VIA RECOGNITION OF AMINO ACIDS BY CUCURBIT[8]URIL

Rowland, M.J.^; Appel, E.A.^; Coulston, R.; Scherman, O.A.* Journal of Materials Chemistry B (2013) PDF

TRIGGERED INSULIN RELEASE STUDIES OF TRIPLY RESPONSIVE SUPRAMOLECULAR MICELLES

Loh, X.J.; Tsai, M.-H.; del Barrio, J.; Appel, E.A.; Scherman, O.A.* Polymer Chemistry (2012) PDF

TRIPLY TRIGGERED DOXORUBICIN RELEASE FROM SUPRAMOLECULAR NANOCONTAINERS

Loh, X.J.; del Barrio, J.; Toh, P.P.C.; Lee, T.-C.; Jiao, D.; Rauwald, U.; Appel, E.A.; Scherman, O.A.* Biomacromolecules (2012) PDF

HIGH MOLECULAR WEIGHT POLYACRYLAMIDES BY ATRP: ENABLING ADVANCEMENTS IN WATER-BASED APPLICATIONS

Appel, E.A.; del Barrio, J.; Loh, X.J.; Dyson, J.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2012) PDF

BIODEGRADABLE NANOGEL STAR POLYMERS VIA ORGANOCATALYTIC ROP

Appel, E.A.; Lee, V.Y.; Nguyen, T.T.; McNeil, M.; Hedrick, J.L.; Miller, R.D.*; Sly, J.* Chemical Communications (2012) PDF

SUPRAMOLECULAR POLYMERIC HYDROGELS

Appel, E.A.; del Barrio, J.; Loh, X.J.; Scherman, O.A.* Chemical Society Reviews (2012) PDF

ENHANCED STABILITY AND ACTIVITY OF TEMOZOLOMIDE IN PRIMARY GBM CELLS WITH CUCURBIT[n]URIL

Appel, E.A.^; Rowland, M.J.^; Loh, X.J.; Heywood, R.M.; Watts, C.; Scherman, O.A.* Chemical Communications (2012) PDF

SUSTAINED RELEASE OF PROTEINS FROM A HIGH-WATER-CONTENT SUPRAMOLECULAR POLYMERIC HYDROGEL

Appel, E.A.; Loh, X.J.; Jones, S.T.; Dreiss, C.A.; Scherman, O.A.* Biomaterials (2012) PDF

ULTRAHIGH-WATER-CONTENT HYDROGELS FROM RENEWABLE RESOURCES EXHIBITING MULTI-STIMULI RESPONSIVENESS

Appel, E.A.; Loh, X.J.; Jones, S.T.; Biedermann, F.; Dreiss, C.A.; Scherman, O.A.* Journal of the American Chemical Society (2012) PDF

METASTABLE SINGLE-CHAIN POLYMER NANOPARTICLES PREPARED BY DYNAMIC CROSSLINKING WITH NOR-SECO-CUCURBIT[10]URIL

Appel, E.A.; Dyson, J.; del Barrio, J.; Isaacs, L.; Scherman, O.A.* Chemical Science (2012) PDF

FORMATION OF SINGLE-CHAIN POLYMER NANOPARTICLES IN WATER THROUGH HOST-GUEST INTERACTIONS

Appel, E.A.; Dyson, J.; del Barrio, J.; Walsh, Z.; Scherman, O.A.* Angewandte Chemie International Edition (2012) PDF
- highlighted as a ''Hot Paper'' by the editors of Angew. Chem. Int. Ed. 

POST-POLYMERIZATION MODIFICATION OF HYDROXYL-FUNCTIONALIZED POLYMERS WITH ISOCYANATES

Biedermann, F.; Appel, E.A.; del Barrio, J.; Gruendling, T.; Barner-Kowollik, C.; Scherman, O.A.* Macromolecules (2011) PDF

SUPRAMOLECULAR GOLD NANOPARTICLE-POLYMER COMPOSITES FORMED IN WATER WITH CUCURBIT[8]URIL

Coulston, R.J.; Jones, S.T.; Lee, T.-C.; Appel, E.A.; Scherman, O.A.* Chemical Communications (2011) PDF

SUPRAMOLECULAR CROSS-LINKED NETWORKS VIA HOST-GUEST COMPLEXATION WITH CUCURBIT[8]URIL

Appel, E.A.; Biedermann, F.; Rauwald, U.; Zayed, J.M.; Scherman, O.A.* Journal of the American Chemical Society (2010) PDF
- highlighted in ''Hosting Hydrogel Formation,'' Synfacts (2010)

HIERARCHICAL SUPERMOLECULAR STRUCTURES FOR SUSTAINED DRUG RELEASE

Tan, J.P.K.; Kim, S.H.; Nederberg, F.; Appel, E.A.; Waymouth, R.M.; Zhang, Y.; Hedrick, J.L.*; Yang, Y.Y.* Small (2009) PDF

SIMPLE APPROACH TO STABILIZED MICELLES EMPLOYING MIKTOARM TERPOLYMERS AND STEREOCOMPLEXES WITH APPLICATION IN PACLITAXEL DELIVERY

Nederberg, F.; Appel, E.A.; Tan, J.P.K.; Kim, S.H.; Fukushima, K.; Sly, J.; Miller, R.D.; Waymouth, R. M.*; Yang, Y. Y.*; Hedrick, J. L.* Biomacromolecules (2009) PDF