http://www.supramolecularbiomaterials.com/2009 daily 0.75 2016-12-03 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740354276-QLTO8712Q0SHX5RACV34/999.png 2009 HIERARCHICAL SUPERMOLECULAR STRUCTURES FOR SUSTAINED DRUG RELEASE Tan, J.P.K.; Kim, S.H.; Nederberg, F.; Appel, E.A.; Waymouth, R.M.; Zhang, Y.; Hedrick, J.L.*; Yang, Y.Y.* Small (2009) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740354276-QLTO8712Q0SHX5RACV34/999.png 2009 HIERARCHICAL SUPERMOLECULAR STRUCTURES FOR SUSTAINED DRUG RELEASE Tan, J.P.K.; Kim, S.H.; Nederberg, F.; Appel, E.A.; Waymouth, R.M.; Zhang, Y.; Hedrick, J.L.*; Yang, Y.Y.* Small (2009) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740353877-2V923YX1HQWTTJPTSFLL/1000.png 2009 SIMPLE APPROACH TO STABILIZED MICELLES EMPLOYING MIKTOARM TERPOLYMERS AND STEREOCOMPLEXES WITH APPLICATION IN PACLITAXEL DELIVERY Nederberg, F.; Appel, E.A.; Tan, J.P.K.; Kim, S.H.; Fukushima, K.; Sly, J.; Miller, R.D.; Waymouth, R. M.*; Yang, Y. Y.*; Hedrick, J. L.* Biomacromolecules (2009) PDF http://www.supramolecularbiomaterials.com/2010 daily 0.75 2016-12-03 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740370556-PSVBDEHCSDGEEZDFUFY8/998.png 2010 SUPRAMOLECULAR CROSS-LINKED NETWORKS VIA HOST-GUEST COMPLEXATION WITH CUCURBIT[8]URIL Appel, E.A.; Biedermann, F.; Rauwald, U.; Zayed, J.M.; Scherman, O.A.* Journal of the American Chemical Society (2010) PDF - highlighted in ''Hosting Hydrogel Formation,'' Synfacts (2010) https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740370556-PSVBDEHCSDGEEZDFUFY8/998.png 2010 SUPRAMOLECULAR CROSS-LINKED NETWORKS VIA HOST-GUEST COMPLEXATION WITH CUCURBIT[8]URIL Appel, E.A.; Biedermann, F.; Rauwald, U.; Zayed, J.M.; Scherman, O.A.* Journal of the American Chemical Society (2010) PDF - highlighted in ''Hosting Hydrogel Formation,'' Synfacts (2010) http://www.supramolecularbiomaterials.com/2011 daily 0.75 2016-12-03 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740385242-YWAT1G57OGIIA483UA82/996.png 2011 POST-POLYMERIZATION MODIFICATION OF HYDROXYL-FUNCTIONALIZED POLYMERS WITH ISOCYANATES Biedermann, F.; Appel, E.A.; del Barrio, J.; Gruendling, T.; Barner-Kowollik, C.; Scherman, O.A.* Macromolecules (2011) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740385242-YWAT1G57OGIIA483UA82/996.png 2011 POST-POLYMERIZATION MODIFICATION OF HYDROXYL-FUNCTIONALIZED POLYMERS WITH ISOCYANATES Biedermann, F.; Appel, E.A.; del Barrio, J.; Gruendling, T.; Barner-Kowollik, C.; Scherman, O.A.* Macromolecules (2011) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740385341-MS2089GH502ANXXILFES/997.png 2011 SUPRAMOLECULAR GOLD NANOPARTICLE-POLYMER COMPOSITES FORMED IN WATER WITH CUCURBIT[8]URIL Coulston, R.J.; Jones, S.T.; Lee, T.-C.; Appel, E.A.; Scherman, O.A.* Chemical Communications (2011) PDF http://www.supramolecularbiomaterials.com/2012 daily 0.75 2016-12-09 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740570363-5LXCEOUGYCFPVUDL402E/986.png 2012 TRIGGERED INSULIN RELEASE STUDIES OF TRIPLY RESPONSIVE SUPRAMOLECULAR MICELLES Loh, X.J.; Tsai, M.-H.; del Barrio, J.; Appel, E.A.; Scherman, O.A.* Polymer Chemistry (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740570363-5LXCEOUGYCFPVUDL402E/986.png 2012 TRIGGERED INSULIN RELEASE STUDIES OF TRIPLY RESPONSIVE SUPRAMOLECULAR MICELLES Loh, X.J.; Tsai, M.-H.; del Barrio, J.; Appel, E.A.; Scherman, O.A.* Polymer Chemistry (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740570640-5PU7H9GI3W8LRWL6DQ73/987.png 2012 TRIPLY TRIGGERED DOXORUBICIN RELEASE FROM SUPRAMOLECULAR NANOCONTAINERS Loh, X.J.; del Barrio, J.; Toh, P.P.C.; Lee, T.-C.; Jiao, D.; Rauwald, U.; Appel, E.A.; Scherman, O.A.* Biomacromolecules (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740570550-WAR90XWRK5DTXW2H733R/988.png 2012 HIGH MOLECULAR WEIGHT POLYACRYLAMIDES BY ATRP: ENABLING ADVANCEMENTS IN WATER-BASED APPLICATIONS Appel, E.A.; del Barrio, J.; Loh, X.J.; Dyson, J.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740571312-F03SUHUVZMRK9QC4C4B7/989.png 2012 BIODEGRADABLE NANOGEL STAR POLYMERS VIA ORGANOCATALYTIC ROP Appel, E.A.; Lee, V.Y.; Nguyen, T.T.; McNeil, M.; Hedrick, J.L.; Miller, R.D.*; Sly, J.* Chemical Communications (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740571152-B4QD8UYBRF7KZMHD3Y64/990.png 2012 SUPRAMOLECULAR POLYMERIC HYDROGELS Appel, E.A.; del Barrio, J.; Loh, X.J.; Scherman, O.A.* Chemical Society Reviews (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740572535-AACTVEUK1FR0AH6PXENK/991.png 2012 ENHANCED STABILITY AND ACTIVITY OF TEMOZOLOMIDE IN PRIMARY GBM CELLS WITH CUCURBIT[n]URIL Appel, E.A.^; Rowland, M.J.^; Loh, X.J.; Heywood, R.M.; Watts, C.; Scherman, O.A.* Chemical Communications (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740571938-N6FEEB1GCT9IU8T9ADUQ/992.png 2012 SUSTAINED RELEASE OF PROTEINS FROM A HIGH-WATER-CONTENT SUPRAMOLECULAR POLYMERIC HYDROGEL Appel, E.A.; Loh, X.J.; Jones, S.T.; Dreiss, C.A.; Scherman, O.A.* Biomaterials (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740572457-Q4NLDJ940U4MU96DTWS9/993.png 2012 ULTRAHIGH-WATER-CONTENT HYDROGELS FROM RENEWABLE RESOURCES EXHIBITING MULTI-STIMULI RESPONSIVENESS Appel, E.A.; Loh, X.J.; Jones, S.T.; Biedermann, F.; Dreiss, C.A.; Scherman, O.A.* Journal of the American Chemical Society (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740572632-1KSLN07CICUU2EXI6XMN/994.png 2012 METASTABLE SINGLE-CHAIN POLYMER NANOPARTICLES PREPARED BY DYNAMIC CROSSLINKING WITH NOR-SECO-CUCURBIT[10]URIL Appel, E.A.; Dyson, J.; del Barrio, J.; Isaacs, L.; Scherman, O.A.* Chemical Science (2012) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740572693-UBUFO8VQ9IRA3JG1W9ZN/995.png 2012 FORMATION OF SINGLE-CHAIN POLYMER NANOPARTICLES IN WATER THROUGH HOST-GUEST INTERACTIONS Appel, E.A.; Dyson, J.; del Barrio, J.; Walsh, Z.; Scherman, O.A.* Angewandte Chemie International Edition (2012) PDF - highlighted as a ''Hot Paper'' by the editors of Angew. Chem. Int. Ed. http://www.supramolecularbiomaterials.com/2013 daily 0.75 2016-12-09 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740589203-GHSIPUFALWJK7RNGUY2L/985.png 2013 DYNAMICALLY CROSSLINKED MATERIALS VIA RECOGNITION OF AMINO ACIDS BY CUCURBIT[8]URIL Rowland, M.J.^; Appel, E.A.^; Coulston, R.; Scherman, O.A.* Journal of Materials Chemistry B (2013) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740589203-GHSIPUFALWJK7RNGUY2L/985.png 2013 DYNAMICALLY CROSSLINKED MATERIALS VIA RECOGNITION OF AMINO ACIDS BY CUCURBIT[8]URIL Rowland, M.J.^; Appel, E.A.^; Coulston, R.; Scherman, O.A.* Journal of Materials Chemistry B (2013) PDF http://www.supramolecularbiomaterials.com/2014 daily 0.75 2016-12-09 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740616731-M1JUHWPULA0Q1AMOUB6I/981.png 2014 NON-CELL-ADHESIVE SUBSTRATES FOR PRINTING OF ARRAYED BIOMATERIALS Appel, E.A.; Larson, B.L.; Luly, K.M.; Kim, J.D.; Langer, R.* Advanced Healthcare Materials (2014) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740616731-M1JUHWPULA0Q1AMOUB6I/981.png 2014 NON-CELL-ADHESIVE SUBSTRATES FOR PRINTING OF ARRAYED BIOMATERIALS Appel, E.A.; Larson, B.L.; Luly, K.M.; Kim, J.D.; Langer, R.* Advanced Healthcare Materials (2014) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740616657-TBBG8RO4RN8T9DDNYEPI/982.png 2014 HEALABLE, STABLE AND STIFF HYDROGELS: COMBINING CONFLICTING PROPERTIES USING DYNAMIC AND SELECTIVE THREE-COMPONENT RECOGNITION WITH REINFORCING CELLULOSE NANORODS Mckee, J.^; Appel, E.A.^; Seitsonen, J.; Kontturi, E.; Scherman, O.A.*; Ikkala, O.* Advanced Functional Materials (2014) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740617169-L2MQR9FGF96Y1OZ46UQW/983.png 2014 THE CONTROL OF CARGO RELEASE FROM PHYSICALLY CROSSLINKED HYDROGELS BY CROSSLINK DYNAMICS Appel, E.A.; Forster, R.A.; Rowland, M.J.; Scherman, O.A.* Biomaterials (2014) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740617701-TCPNKVT1QYMTRRDAGP6D/984.png 2014 ACTIVATION ENERGIES CONTROL MACROSCOPIC PROPERTIES OF PHYSICALLY CROSSLINKED MATERIALS Appel, E.A.; Forster, R.A.; Koutsiobas, A.; Toprakcioglu, C.; Scherman, O.A.* Angewandte Chemie International Edition (2014) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1480831413031-6SBXZBRJ2A4AJFVQ9DOA/981a.png 2014 GLUING GELS: A NANOPARTICLE SOLUTION Appel, E.A.* and Scherman, O.A.* Nature Materials (2014) PDF http://www.supramolecularbiomaterials.com/2015 daily 0.75 2016-12-09 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740637108-NRRVN4VGX33VRX1AMOI5/975.png 2015 WATER SOLUBLE, BIODEGRADABLE AMPHIPHILIC POLYMERIC NANOPARTICLES AND THE MOLECULAR ENVIRONMENT OF HYDROPHOBIC ENCAPSULATES: CONSISTENCY BETWEEN SIMULATION AND EXPERIMENT Miller, R.D.*; Yusoff, R.M.; Swope, W.C.; Rice, J.E.; Carr, A.C.; Parker, A.J.; Sly, J.; Appel, E.A.; Nguyen, R.; Piunova, V. Polymer (2015) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740637108-NRRVN4VGX33VRX1AMOI5/975.png 2015 WATER SOLUBLE, BIODEGRADABLE AMPHIPHILIC POLYMERIC NANOPARTICLES AND THE MOLECULAR ENVIRONMENT OF HYDROPHOBIC ENCAPSULATES: CONSISTENCY BETWEEN SIMULATION AND EXPERIMENT Miller, R.D.*; Yusoff, R.M.; Swope, W.C.; Rice, J.E.; Carr, A.C.; Parker, A.J.; Sly, J.; Appel, E.A.; Nguyen, R.; Piunova, V. Polymer (2015) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740637092-4RWQOKX8KUZFPZ7HQ8K9/976.png 2015 FORMATION OF CUCURBIT[8]URIL-BASED SUPRAMOLECULAR HYDROGEL BEADS USING DROPLET-BASED MICROFLUIDICS Xu, X.; Appel, E.A.; Liu, X.; Parker, R.; Scherman, O.A.; Abell, C.* Biomacromolecules (2015) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740638048-UAM03F2KSSWYM6LJNU1T/977.png 2015 EXPLOITING ELECTROSTATIC INTERACTIONS IN POLYMER-NANOPARTICLE HYDROGELS Appel, E.A.; Tibbitt, M.W.; Greer, J.M.; Fenton, O.S.; Kreuels, K.; Anderson, D.G.; Langer, R.* ACS Macro Letters (2015) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740638352-21BGB4EBQBNCURI8EJFZ/978.png 2015 SELF-ASSEMBLED HYDROGELS UTILISING POLYMER-NANOPARTICLE INTERACTIONS Appel, E.A.^; Tibbitt, M.W.^; Webber, M.J.; Mattix, B.A.; Veiseh, O.; Langer, R.* Nature Communications (2015) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740639927-OGY45M6SUTWX676N697T/979.png 2015 A FACILE METHOD FOR THE STAIN-FREE VISUALIZATION OF HIERARCHICAL STRUCTURES WITH ELECTRON MICROSCOPY Williams, P.E.; Appel, E.A.; Jones, S.T.; del Barrio, J.; Lan, Y.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2015) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1446740638649-RYTJ2MKODSSEGBJPYQME/980.png 2015 SYNTHESIS OF CONDUCTING POLYMER-METAL NANOPARTICLE HYBRIDS VIA RAFT POLYMERIZATION Williams, P.E.; Jones, S.T.; Walsh, Z.; Appel, E.A.; Abo-Hamed, E.K.; Scherman, O.A.* ACS Macro Letters (2015) PDF http://www.supramolecularbiomaterials.com/group daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1647215433195-89STHTSRZNI5UM050VPQ/Eric_Square.jpg Members ERIC A. APPEL (he/him/his) Principal Investigator eappel AT stanford DOT edu https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1647215433195-89STHTSRZNI5UM050VPQ/Eric_Square.jpg Members ERIC A. APPEL (he/him/his) Principal Investigator eappel AT stanford DOT edu https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1588091060441-SMWZYL47NAHVJO2N3GDV/Annie+Hall+Picture.PNG Members ANNIE HALL (she/her/hers) Administrative Associate Materials Science & Engineering amthall AT stanford DOT edu https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1742688744310-RUHN45FBX5FLPISCZ4F4/Vanessa.jpg Members VANESSA M. 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Stanford University (Materials Science & Engineering) http://www.supramolecularbiomaterials.com/stanford daily 0.75 2015-11-11 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1447282069864-19AXQ1NAMC0Z8110MCGH/stanford_square.png Stanford https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1447282069864-19AXQ1NAMC0Z8110MCGH/stanford_square.png Stanford http://www.supramolecularbiomaterials.com/2016 daily 0.75 2020-07-05 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1480359867419-AVBEU81SHYXDXDQ4DEC6/969.png 2016 SCALABLE MANUFACTURING OF BIOMIMETIC MOLDABLE HYDROGELS FOR INDUSTRIAL APPLICATIONS Yu, A.C.; Chen, H.; Chan, D.; Agmon, G.; Stapleton, L.M.; Sevit, A.M.; Tibbitt, M.W.; Acosta, J.D.; Zhang, T.; Franzia, P.W.; Langer, R.; Appel, E.A.* Proceedings of the National Academy of Sciences (2016) PDF Check out the Stanford News article covering this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1480359867419-AVBEU81SHYXDXDQ4DEC6/969.png 2016 SCALABLE MANUFACTURING OF BIOMIMETIC MOLDABLE HYDROGELS FOR INDUSTRIAL APPLICATIONS Yu, A.C.; Chen, H.; Chan, D.; Agmon, G.; Stapleton, L.M.; Sevit, A.M.; Tibbitt, M.W.; Acosta, J.D.; Zhang, T.; Franzia, P.W.; Langer, R.; Appel, E.A.* Proceedings of the National Academy of Sciences (2016) PDF Check out the Stanford News article covering this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1451316990164-EY628C11OUS9X6NYWZFP/973.png 2016 SUPRAMOLECULAR BIOMATERIALS Webber, M.J.^; Appel, E.A.^; Meijer, E.W.; Langer, R.* Nature Materials (2016) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1480359825391-Y8SV7XUFILI4JMZTA0Z3/970.png 2016 SUPRAMOLECULAR PEGYLATION OF BIOPHARMACEUTICALS Webber, M.J.^; Appel, E.A.^; Vinciguerra, B.; Thapa, L.S.; Cortinas, A.B.; Jhunjhunwala, S.; Isaacs, L.*; Langer, R.*; Anderson, D.G.* Proceedings of the National Academy of Sciences (2016) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1457066461478-YN0BULK0T9T1AJN1WHOZ/972.png 2016 BIOINSPIRED ALKENYL AMINO ALCOHOL IONIZABLE LIPID MATERIALS FOR HIGHLY POTENT IN VIVO MRNA DELIVERY Fenton, O.S.; Kauffman, K.J.; McClellan, R.L.; Appel, E.A.; Dorkin, J.R.; Tibbitt, M.W.; Heartlein, M.W.; DeRosa, F.; Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1461688608227-ZEXXP0PJMCGBL9QFMALJ/974.png 2016 INJECTABLE SELF-HEALING GLUCOSE RESPONSIVE HYDROGELS WITH PH-BASED REGULATED MECHANICAL PROPERTIES Yesilyurt, V.; Webber, M.J.; Appel, E.A.; Godwin, C., Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1471322626159-HG0J8ZBTPN0LZR6NJJ4R/971.png 2016 INJECTABLE AND GLUCOSE-RESPONSIVE HYDROGELS BASED ON BORONIC ACID-GLUCOSE COMPLEXATION Dong, Y.; Wang, W.; Veiseh, O.; Appel, E.A.; Xue, K.; Webber, M.J.; Tang, B.; Yang, X.-W.; Weir, G.; Langer, R.; Anderson, D.G.* Langmuir (2016) PDF http://www.supramolecularbiomaterials.com/alumni daily 0.75 2025-06-15 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1474399536231-ZGN7US6044X6PVT9W4M1/anand.jpg Alumni Summer ANAND POOZHIKUNNEL Summer Undergraduate Researcher Caltech (Chemistry) https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1474399536231-ZGN7US6044X6PVT9W4M1/anand.jpg Alumni Summer ANAND POOZHIKUNNEL Summer Undergraduate Researcher Caltech (Chemistry) https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1511207229106-Z2US6GEDW6R0HC69LJ50/Rachel.jpg Alumni Summer RACHEL WALLSTROM Summer Undergraduate Researcher Stanford University (Materials Science) https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1563473907824-I9PMV22JRZ9VYKGEEUHY/Karime.jpeg Alumni Summer KARIME LABORIN Summer Undergraduate 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Borenstein, J.T.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1487054065326-D7FDZTDUCT0AP11CHMS6/968.png 2017 MIXED REVERSIBLE COVALENT CROSSLINK KINETICS ENABLE PRECISE, HIERARCHICAL MECHANICAL TUNING OF HYDROGEL NETWORKS Yesilyurt, V.^; Ayoob, A.M.^; Appel, E.A.; Borenstein, J.T.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1496683858540-6K3H1ECTSFXQ8P22EJLP/967.png 2017 SINGLE-CHAIN POLYMERIC NANOCARRIERS: A PLATFORM FOR DETERMINING STRUCTURE-FUNCTION CORRELATIONS IN THE DELIVERY OF MOLECULAR CARGO Chan, D.; Yu, A.; Appel, E.A.* Biomacromolecules (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1499398531036-IGBBQXQ8KY5PU1MVWPLK/966.png 2017 SYNTHESIS AND BIOLOGICAL EVALUATION OF IONIZABLE LIPID MATERIALS FOR THE IN VIVO DELIVERY OF MESSENGER RNA TO B LYMPHOCYTES Fenton, O.S.; Kauffman, K.J.; Kaczmarek, J.C.; McClellan, R.L.; Jhunjhunwala, S.; Tibbitt, M.W.; Zeng, M.D.; Appel, E.A.; Dorkin, J.R.; Mir, F.F.; Yang, J.H.; Oberli, M.A.; Heartlein, M.W.; DeRosa, R.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1503016955654-R4C859GEXPWIEBEE63IQ/964.png 2017 DECOUPLED ASSOCIATIVE AND DISSOCIATIVE PROCESSES IN HIGHLY DYNAMIC HOST-GUEST COMPLEXES Appel, E.A.*; Biedermann, F.*; Hoogland, D.; del Barrio, J.; Driscoll, M.D.; Hay, S.; Wales, D.J.; Scherman, O.A.* Journal of the American Chemical Society (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1499399328828-2KUQ4CPTF400UW1GGUZL/965.png 2017 DISTINGUISHING RELAXATION DYNAMICS IN TRANSIENTLY CROSSLINKED POLYMERIC NETWORKS Tan, C.S.Y.; Agmon, G.; Liu, J.; Hoogland, D.; Janecek, E.-R.; Appel, E.A.*; Scherman, O.A.* Polymer Chemistry (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1499819117093-F6U43X68VH0I60PJVY72/963.png 2017 MECHANISTIC UNDERSTANDING OF IN VIVO PROTEIN CORONA FORMATION ON POLYMERIC NANOPARTICLES AND IMPACT ON PHARMACOKINETICS Bertrand, N.; Grenier, P.; Mahmoudi, M.; Lima, E.; Appel, E.A.; Dormont, F.; Lim, J.-M.; Karnik, R.; Langer, R.; Farokhzad, O.* Nature Communications (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1509688090287-7ZW2JU8PXLTJERN0ZMQL/962.png 2017 SUPRAMOLECULAR POLYMERIC BIOMATERIALS Mann, J.L.^; Yu, A.C.^; Agmon, G.; Appel, E.A.* Biomaterials Science (2017) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1512760112730-0740QGVZLQL1I9K2UX26/961.png 2017 ENGINEERING THE MECHANICAL PROPERTIES OF POLYMER NETWORKS WITH PRECISE DOPING OF PRIMARY DEFECTS Chan, D.; Ding, Y.; Dauskardt, R.H.; Appel, E.A.* ACS Applied Materials and Interfaces (2017) PDF http://www.supramolecularbiomaterials.com/lab-construction daily 0.75 2018-02-07 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1488858391516-EYZC4O1KH1MD6FAP1JFS/IMG_1319.JPG Lab Construction https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1488858391516-EYZC4O1KH1MD6FAP1JFS/IMG_1319.JPG Lab Construction https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1488858214751-D08KL9Y5DCBLABDKYZOZ/IMG_1327.JPG Lab Construction https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1493319320248-NOTWUBLR9W9KRIQWW7Q4/IMG_7800.JPG Lab Construction http://www.supramolecularbiomaterials.com/2018 daily 0.75 2019-04-26 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1541028660668-IKV9OUXI8MPM2BSECICH/960.png 2018 NON-NEWTONIAN POLYMER-NANOPARTICLE HYDROGELS ENHANCE CELL VIABILITY DURING INJECTION Lopez Hernandez, H.; Grosskopf, A.K.; Stapleton, L.M.; Agmon, G.; Appel, E.A.* Macromolecular Bioscience (2018) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1541028660668-IKV9OUXI8MPM2BSECICH/960.png 2018 NON-NEWTONIAN POLYMER-NANOPARTICLE HYDROGELS ENHANCE CELL VIABILITY DURING INJECTION Lopez Hernandez, H.; Grosskopf, A.K.; Stapleton, L.M.; Agmon, G.; Appel, E.A.* Macromolecular Bioscience (2018) PDF http://www.supramolecularbiomaterials.com/2019 daily 0.75 2020-11-30 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1570503004740-TOSBJ5AS7LC8C2QLV6W8/955.png 2019 WILDFIRE PREVENTION THROUGH PROPHYLACTIC TREATMENT OF HIGH-RISK LANDSCAPES USING VISCOELASTIC RETARDANT FLUIDS Yu, A.C.; Lopez Hernandez, H.; Kim, A.H.; Stapleton, L.M.; Brand, R.J.; Mellor, E.T.; Bauer, C.P.; McCurdy, G.D.; Wolff, A.J.; Chan, D.; Criddle, C.S.; Acosta, J.D.; Appel, E.A.* Proceedings of the National Academy of Science (2019) PDF, BURN VIDEO, ART Check out the Stanford News article describing this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1570503004740-TOSBJ5AS7LC8C2QLV6W8/955.png 2019 WILDFIRE PREVENTION THROUGH PROPHYLACTIC TREATMENT OF HIGH-RISK LANDSCAPES USING VISCOELASTIC RETARDANT FLUIDS Yu, A.C.; Lopez Hernandez, H.; Kim, A.H.; Stapleton, L.M.; Brand, R.J.; Mellor, E.T.; Bauer, C.P.; McCurdy, G.D.; Wolff, A.J.; Chan, D.; Criddle, C.S.; Acosta, J.D.; Appel, E.A.* Proceedings of the National Academy of Science (2019) PDF, BURN VIDEO, ART Check out the Stanford News article describing this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1565826446019-TBDG6C2OI6S78L9M03CY/957.png 2019 USE OF A SUPRAMOLECULAR POLYMERIC HYDROGEL AS AN EFFECTIVE POST-OPERATIVE PERICARDIAL ADHESION BARRIER Stapleton, L.M.; Steele, A.N.; Wang, H.; Lopez Hernandez, H.; Yu, A.C.; Paulsen, M.J.; Smith, A.A.A.; Roth, G.A.; Thakore, A.D.; Lucian, H.J.; Totherow, K.P.; Baker, S.W.; Tada, Y.; Farry, J.M.; Eskandari, A.; Hironaka, C.E.; Jaatinen, K.J.; Williams, K.M.; Bergamasco, H.; Marschel, C.; Chadwick, B.; Grady, F.; Ma, M.; Appel, E.A.*; Woo, Y.J.* Nature Biomedical Engineering (2019) PDF, COVER ART Check out the Stanford News article describing this work Check out the Nature Bioengineering Research community coverage of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1573079402466-4VWRHR0E371CQYRHFTK0/952.png 2019 A NANOPARTICLE PLATFORM FOR IMPROVED POTENCY, STABILITY, AND ADJUVANTICITY OF POLY(I:C) Gale, E.C.; Roth, G.A.; Smith, A.A.A.; Alcántara-Hernández, M.; Idoyaga, J.; Appel, E.A.* Advanced Therapeutics (2019) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1573526995093-TQC1NJCH1E2URVAK4XTT/WebsiteTOC.png 2019 STABLE MONOMERIC INSULIN FORMULATIONS ENABLED BY SUPRAMOLECULAR PEGYLATION OF INSULIN ANALOGUES Maikawa, C.L.^; Smith, A.A.A.^; Zou, L.; Meis, C.M.; Mann, J.L.; Webber, M.J.; Appel, E.A.* Advanced Therapeutics (2019) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1570503015610-V6B5A8K6AQVY3QS7506F/954.png 2019 INJECTABLE SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS ENHANCE HUMAN MESENCHYMAL STEM CELL DELIVERY Grosskopf, A.K.; Roth, G.A.; Smith, A.A.A.; Gale, E.C.; Lopez Hernandez, H.; Appel, E.A.* Bioengineering & Translational Medicine (2019) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1565840024633-IZ11TYH4Z9DZ1E1KYBQC/956.png 2019 A MULTI-SCALE MODEL FOR SOLUTE DIFFUSION IN HYDROGELS Axpe, E.; Chan, D.; Offeddu, G.S.; Chang, Y.; Merida, D.; Lopez Hernandez, H.; Appel, E.A.* Macromolecules (2019) PDF, CALCULATOR https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1556304695358-FKIO0PDK5O3KGN4YUEUU/959.png 2019 A BIOCOMPATIBLE THERAPEUTIC CATHETER-DELIVERABLE HYDROGEL FOR IN SITU TISSUE ENGINEERING Steele, A.N.; Stapleton, L.M.; Farry, J.M.; Lucian, H.J.; Paulsen, M.J.; Eskandari, A.; Hironaka, C.E.; Thakore, A.D.; Wang, H.; Yu, A.C.; Chan, D.; Appel, E.A.*; Woo, Y.J.* Advanced Healthcare Materials (2019) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1556305610016-9UV4XZVOEKO46FOO9A2K/958.png 2019 BLOCK COPOLYMER COMPOSITION DRIVES FUNCTION OF SELF-ASSEMBLED NANOPARTICLES FOR DELIVERY OF SMALL-MOLECULE CARGO Maikawa, C.L.; Sevit, A.; Lin, B.; Wallstrom, R.J.; Mann, J.L.; Yu, A.C.; Waymouth, R.M.; Appel, E.A.* Journal of Polymer Science: Polymer Chemistry (2019) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1572904162158-65S71GTOKWMLNJKMB47S/953.png 2019 INJECTABLE POLYMER-NANOPARTICLE HYDROGELS FOR LOCAL IMMUNE CELL RECRUITMENT Owen S. Fenton; Mark W. Tibbitt; Eric A. Appel; Siddharth Jhunjhunwala; Matthew J. Webber; Robert Langer* Biomacromolecules (2019) PDF, COVER ART https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1576264968592-4FJPEML3XEGLBMQLA4BV/948.png 2019 UNIVERSAL SCALING BEHAVIOR DURING NETWORK FORMATION IN CONTROLLED RADICAL POLYMERIZATIONS Mann, J.L.; Rossi, R.L.; Smith, A.A.A.; Appel, E.A.* Macromolecules (2019) PDF http://www.supramolecularbiomaterials.com/alumni-phd daily 0.75 2026-01-07 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1592161932851-W0BSPMIXCPPABS5QFABJ/DoreenChan.png Alumni PhD DOREEN CHAN PhD, Chemistry https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1592161932851-W0BSPMIXCPPABS5QFABJ/DoreenChan.png Alumni PhD DOREEN CHAN PhD, Chemistry https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1457034411503-TFFYQSCH7CQ0RGMC496U/LyndsayStapleton.jpg Alumni PhD LYNDSAY M. STAPLETON PhD, Bioengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1463165990005-OYWQQHYG7PLFHASINOAX/Headshot.png Alumni PhD ANTHONY C. YU PhD, Materials Science & Engineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1461181474288-VZKVA4UAX0WNXQ7UYWHA/Gillie_square.jpg Alumni PhD GILLIE A. ROTH PhD, Bioengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1474337992733-5D69KPBCLITDPKS85SMK/Mann_Joseph.jpg Alumni PhD JOSEPH L. MANN PhD, Materials Science & Engineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1550640185626-DMRGINES7M9B564UJY1F/20190217_25-2.jpg Alumni PhD EMILY C. GALE PhD, Biochemistry https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1493156108515-VY30DWX0F1BEKVA64OFE/headshot.jpeg Alumni PhD CAITLIN MAIKAWA PhD, Bioengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1539735014240-EKN6FWUI1SSUNE662E7X/CelineLiong_AppelGroup.jpg Alumni PhD CELINE LIONG PhD, Bioengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1517015586220-RPUOXBJGIYYF7QI88O5J/Meis.jpg Alumni PhD CATIE KASSE PhD, Materials Science & Engineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1522709824129-PDQZ1VB5XOP3GG2W6ZHC/Abby_Grosskopf.PNG Alumni PhD ABIGAIL K. GROSSKOPF PhD, Chemical Engineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1578373660961-V6DZKNZNCYBMPD1ADN9B/Olivia.jpg Alumni PhD OLIVIA M. SAOUAF PhD, Materials Science & Engineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1578373705873-72C2TMM8EZ3JZQC9YVJW/Ben.jpg Alumni PhD BEN OU PhD, Bioengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1590205016943-VXEBH8UD48F8UFE6FS3Q/EW2A5431-%28ZF-6303-47775-1-003%29.jpg Alumni PhD EMILY MEANY PhD, Bioengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1614722447092-QDW01WM1MSKZALRCNNZI/LesleeNguyen_LabPhoto2.JPG Alumni PhD LESLEE T. NGUYEN PhD, Biochemistry https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1622583571951-0VMT5AT1B7AVSU2O9WVZ/Jerry+Yan.jpg Alumni PhD JERRY YAN PhD, Bioengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1604094561985-7WOOS0KBZXUZD7OHO835/CarolynHeadshot.jpg Alumni PhD CAROLYN K. JONS PhD, Materials Science & Engineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1621443443862-58UBP7WGK261JCQTO95R/ShoshanaWilliams.jpeg Alumni PhD SHOSHANA C. WILLIAMS (she/her/hers) PhD Student Chemistry scwillia AT stanford DOT edu https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1618977554679-YJWGIYHLXD5C23J3S3E9/Profile+Picture.JPG Alumni PhD JOHN H. KLICH (he/him/his) PhD Student Bioengineering jhklich AT stanford DOT edu http://www.supramolecularbiomaterials.com/alumni-summer daily 0.75 2025-10-31 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1492232364758-PD4GE2L4G3SEQSUPEOJ2/alex.jpg Alumni Undergrad & MS Students ALEX SEVIT MS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1492232364758-PD4GE2L4G3SEQSUPEOJ2/alex.jpg Alumni Undergrad & MS Students ALEX SEVIT MS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1501638930407-BOOJW831XDZTON9FMVM1/haoxuan.JPG Alumni Undergrad & MS Students HAOXUAN CHEN MS, Materials Science & Engineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1563473928074-2XURNTSFE7HYAYN56ESP/Rachel.jpg Alumni Undergrad & MS Students RACHEL LOUISE ROSSI BS, Chemical Engineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1532492414952-PDWG6EV3H6RPH3M6T0VS/Awua+Headshot.jpg Alumni Undergrad & MS Students AWUA BUAHIN BS, Materials Science & Engineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1574390182199-1FF6424JZ599PVPFB3V8/Sarah.jpg Alumni Undergrad & MS Students SARAH R. SCHISLA BS, Chemical Engineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1520450455460-GNCBOWX9KS8IWRIWI1CN/Neil.jpg Alumni Undergrad & MS Students NEIL J. PATEL BS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1594272895333-QOS2A34XCH53C4GDN8JL/PEYTON_CHEN_photo.jpg Alumni Undergrad & MS Students PEYTON CHEN BS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1606186677234-CS53Y4R3LIELQFGHJ6K3/Brigitte.jpeg Alumni Undergrad & MS Students BRIGITTE L. SCHMITTLEIN MS, Materials Science & Engineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1594272761562-G60RYM1UOLWROGQOPSHC/Eric.jpg Alumni Undergrad & MS Students ERIC VUONG BS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1646272035629-4IN6CY1Y9G9J07W5V1AT/Maya.jpg Alumni Undergrad & MS Students MAYA WRIGHT AS, Public Health Foothill College https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1656528913844-V4UX2NMC0MQV9CKBFBFQ/Lucia.jpg Alumni Undergrad & MS Students LUCIA MORRIS BS+MS, Computer Science Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1688667130885-E5IPM1O49OKPNT1P7HBU/Montana.jpeg Alumni Undergrad & MS Students MONTANA LAGAT BS, Materials Science & Engineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1665253773800-L6RMDN07N8SRJ6SR5B82/Ryan_Kashanchi.jpg Alumni Undergrad & MS Students RYAN KASHANCHI BS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1629346021451-3F31DR9JK1CASZK9UE5L/Screen+Shot+2020-02-08+at+3.08.25+PM.png Alumni Undergrad & MS Students IAN HALL BS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1665253989899-ZPOXYJ5P9TAMOZDVLHXY/Jesus.jpg Alumni Undergrad & MS Students JESUS PAREDES BS, Bioengineering Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1604077398443-Z6XM7KZPO5QSTX4LUXQM/Katie.jpg Alumni Undergrad & MS Students KATIE LU BS, Biology Stanford University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1647215373499-ODVE6UKAGQYSHI1H5ZOX/Headshot+%281%29.jpg Alumni Undergrad & MS Students GRACE JIANG BS, Bioengineering Stanford University http://www.supramolecularbiomaterials.com/alumni-postdoc daily 0.75 2025-10-07 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1501639168098-FJ27FP43OCK4W2LU3H2L/AntonFront.jpg Alumni Post-doc ANTON A. A. AUTZEN Novo Nordisk Foundation Fellowship Faculty, Technical University of Denmark Nanosmithery https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1501639168098-FJ27FP43OCK4W2LU3H2L/AntonFront.jpg Alumni Post-doc ANTON A. A. AUTZEN Novo Nordisk Foundation Fellowship Faculty, Technical University of Denmark Nanosmithery https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1511206418956-7A033UUN08UZW32SDRT8/Hector.jpg Alumni Post-doc HECTOR LOPEZ HERNANDEZ AGEP Fellowship https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1563476200691-T15VQ1G09R5PJCGVS5FZ/axpe.jpg Alumni Post-doc ENEKO AXPE Marie Curie Postdoctoral Fellowship https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1538700736379-P2DBKSXP3SBZZ1M4NF6I/santi_0575.jpg Alumni Post-doc SANTIAGO CORREA NIH NRSA Fellowship Faculty, Columbia University Nanoscale Immunoengineering https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1580344130117-0J9VR9A2NPLEZF7UV3OM/Andrea.jpg Alumni Post-doc ANDREA D’AQUINO Schmidt Science Postdoctoral Fellowship https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1604438118871-GHCXUITCLUR1S3FUESWT/JulieBaillet.jpg Alumni Post-doc JULIE BAILLET Marie Curie Postdoctoral Fellowship MIT - Nottingham Research Fellow https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1679453254124-HKMS9VS2GSQERA7ZY7VJ/Sophia+Bailey+copy.jpg Alumni Post-doc SOPHIA BAILEY Baker Fellow Faculty, Oregon State University https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1665164290978-6QOCREIECSXGV9I4Y0HE/Samya.jpg Alumni Post-doc SAMYA SEN Postdoctoral Research Associate Faculty, IIT Madras http://www.supramolecularbiomaterials.com/2020 daily 0.75 2021-02-02 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1593906721032-BEIVKR15G08NHEXBL4PB/943.png 2020 INJECTABLE HYDROGELS FOR SUSTAINED CO-DELIVERY OF SUBUNIT VACCINES ENHANCE HUMORAL IMMUNITY Roth, G.A.; Gale, E.C.; Alcantara Herandez, M.; Luo, W.; Axpe, E.; Verma, R.; Yin, Q.; Yu, A.C.; Lopez Hernandez, H.; Maikawa, C.L.; Smith, A.A.A.; Davis, M.M.; Pulendran, B.; Idoyaga, I.; Appel, E.A.* ACS Central Science (2020) PDF Check out the American Chemical Society press coverage Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1593906721032-BEIVKR15G08NHEXBL4PB/943.png 2020 INJECTABLE HYDROGELS FOR SUSTAINED CO-DELIVERY OF SUBUNIT VACCINES ENHANCE HUMORAL IMMUNITY Roth, G.A.; Gale, E.C.; Alcantara Herandez, M.; Luo, W.; Axpe, E.; Verma, R.; Yin, Q.; Yu, A.C.; Lopez Hernandez, H.; Maikawa, C.L.; Smith, A.A.A.; Davis, M.M.; Pulendran, B.; Idoyaga, I.; Appel, E.A.* ACS Central Science (2020) PDF Check out the American Chemical Society press coverage Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1593910244275-WQ1CRXIF0N84JDJIOT8D/941.png 2020 AN ULTRAFAST INSULIN FORMULATION ENABLED BY HIGH-THROUGHPUT SCREENING OF ENGINEERED POLYMERIC EXCIPIENTS Mann, J.L.^; Maikawa, C.L.^; Smith, A.A.A.; Grosskopf, A.K.; Baker, S.W.; Roth, G.A.; Meis, C.M.; Gale, E.C.; Liong, C.S.; Correa, S.; Chan, D.; Stapleton, L.S.; Yu, A.C.; Muir, B.; Howard, S.; Postma, A.; Appel, E.A.* Science Translational Medicine (2020) PDF Check out the Stanford News article describing this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1589305870999-UNKAPFH6D4V0M88CA2ID/946.png 2020 A CO-FORMULATION OF SUPRAMOLECULARLY STABILIZED INSULIN AND PRAMLINTIDE ENHANCES MEALTIME GLUCAGON SUPPRESSION IN DIABETIC PIGS Maikawa, C.L.; Smith, A.A.A.; Zou, L.; Roth, G.A.; Gale, E.C.; Stapleton, L.M.; Baker, S.W.; Mann, J.L.; Yu, A.C.; Correa, S.; Grosskopf, A.K.; Liong, C.S.; Meis, C.M.; Chan, D.; Troxell, M.; Maahs, D.M.; Buckingham, B.A.; Webber, M.J.; Appel, E.A.* Nature Biomedical Engineering (2020) PDF Check out the News & Views from K. 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Chen, P.C.; Vuong, E.T.; Nguyen, L.T.; Mann, J.L.; d’Aquino, A.I.; Lal, R.A.; Maahs, D.M.; Buckingham, B.A.; Appel, E.A.* Advanced Science (2021) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1609964024806-WWNM2NYRXEYUBPNBL631/926.png 2021 PROLONGED CODELIVERY OF HEMAGGLUTININ AND A TLR7/8 AGONIST IN A SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGEL ENHANCES POTENCY AND BREADTH OF INFLUENZA VACCINATION Roth, G.A.^; Saouaf, O.M.^; Smith, A.A.A.; Gale, E.C.; Alcantara Hernandez, M.; Idoyaga, J.; Appel, E.A.* ACS Biomaterials Science & Engineering (2021) PDF This article was featured in the Nanomedicine Advances in Infectious Disease special issue https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1618338665578-OQSWNQWT9N0IWIA8GEMR/927.png 2021 MODULATION OF INJECTABLE HYDROGEL PROPERTIES FOR SLOW CO-DELIVERY OF INFLUENZA SUBUNIT VACCINE COMPONENTS ENHANCES THE POTENCY OF HUMORAL IMMUNITY Saouaf, O.M.; Roth, G.A.; Ou, B.; Smith, A.A.A.; Yu, A.C.; Gale, E.C.; Grosskopf, A.K.; Picece, V.C.T.M.; Appel, E.A.* Journal of Biomedical Materials Research: Part A (2021) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1607805682300-TFK8S6581O4FS4N1PPLQ/931.png 2021 DYNAMIC HYDROGELS FOR PREVENTION OF POST-OPERATIVE PERITONEAL ADHESIONS Stapleton, L.M.; Lucian, H.J.; Grosskopf, A.K.; Smith, A.A.A.; Totherow, K.P.; Woo, Y.J.*; Appel, E.A.* Advanced Therapeutics (2021) PDF Check out the Advanced Science News press coverage https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1617166607940-QCWUW5VMFCXBA227AWKG/921.png 2021 ENGINEERING INSULIN COLD CHAIN RESILIENCE TO IMPROVE GLOBAL ACCESS Maikawa, C.L.^; Mann, J.L.^; Kannan, A.; Meis, C.M.; Ou, B.S.; Smith, A.A.A.; Fuller, G.G.; Maahs, D.M.; Appel, E.A.* Biomacromolecules PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1630432261013-UX4KSAULBU398A8I1N1R/909.png 2021 GELATION AND YIELDING BEHAVIOR OF POLYMER-NANOPARTICLE HYDROGELS Grosskopf, A.K.; Saouaf, O.M.; Lopez Hernandez, H.; Appel, E.A.* Journal of Polymer Science (2021) PDF Check out the ChemRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1613010376711-SCCRL9HDQGXVVZ8MRS3P/923.png 2021 ENHANCED HUMORAL IMMUNE RESPONSE BY HIGH DENSITY TLR AGONIST PRESENTATION ON HYPERBRANCHED POLYMERS Liong, C.S.^; Smith, A.A.A.^; Mann, J.L.; Roth, G.A.; Gale, E.C.; Maikawa, C.L.; Ou, B.S.; Appel, E.A.* Advanced Therapeutics (2021) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1626407015674-XOXL1RNMKD8MP0N5JCRW/910.png 2021 AFFINITY-DIRECTED DYNAMICS OF HOST-GUEST MOTIFS FOR PHARMACOKINETIC MODULATION VIA SUPRAMOLECULAR PEGYLATION Maikawa, C.L.; d’Aquino, A.I.; Vuong, E.T.; Su, B.; Zou, L.; Chen, P.C.; Nguyen, L.T.; Autzen, A.A.A.; Mann, J.L.; Webber, M.J.*; Appel, E.A.* Biomacromolecules PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1616894884491-27D7X3VJ9N8VQRKRR34W/922.png 2021 CONTROLLING PROPERTIES OF THERMOGELS BY TUNING CRITICAL SOLUTION BEHAVIOUR OF TERNARY COPOLYMERS Smith, A.A.A.; Maikawa, C.L.; Lopez Hernandez, H.; Appel, E.A.* Polymer Chemistry (2021) PDF This article was featured in the Pioneering Investigators 2021 special collection https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1617166593196-UG7B9EW6YH0OMGUP67I8/920.png 2021 FULL CLOSED-LOOP OPEN-SOURCE ALGORITHM PERFORMANCE COMPARISON IN PIGS WITH DIABETES Lal, R.A.^; Maikawa, C.L.^; Lewis, D.; Baker, S.W.; Smith, A.A.A.; Roth, G.A.; Gale, E.C.; Stapleton, L.M.; Mann, J.L.; Yu, A.C.; Correa, S.; Grosskopf, A.K.; Liong, C.S.; Meis, C.M.; Chan, D.; Garner, J.P.; Maahs, D.M.; Buckingham, B.A.; Appel, E.A.* Clinical & Translational Medicine (2021) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1608078823739-NWNUGXD597GPYW0ENJX9/929.png 2021 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1608079677084-7VNLZEO70M1QCP0WQIX4/929.png 2021 SEASONAL IMPACT OF PHOSPHATE-BASED FIRE RETARDANTS ON SOIL CHEMISTRY FOLLOWING PROPHYLACTIC TREATMENT OF VEGETATION Yu, A.C.; 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Ikeda, G.; von Bornstadt, D.; Santoso, M.R.; Wahlquist, C.; Rhee, S.; Jeon, Y.-J.; Yu, A.C.; O’brien, C.G.; Red-Horse, K.; Appel, E.A.; Mercola, M.; Woo, J.Y.; Yang, P.C.* Basic Research in Cardiology (2021) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1626148348954-M45P9WUDDUOXLULDRTDK/911.png 2021 ISTHMIN-1 IS AN ADIPOKINE THAT PROMOTES GLUCOSE UPDATE AND IMPROVES GLUCOSE TOLERANCE AND HEPATIC STEATOSIS Jiang, Z.; Zhao, M.; Voilquin, L.; Jung, Y.; Aikio, M.A.; Sahai, T.; Dou, F.; Roche, A.; Carcamo-Orive, I.; Knowles, J.W.; Wabitsch, M.; Appel, E.A.; Maikawa, C.L.; Camporez, J.P.; Shulman, G.I.; Tsai, L.; Rosen, E.D.; Gardner, C.D.; Spiegelman, B.M.; Svensson, K.J.* Cell Metabolism (2021) PDF http://www.supramolecularbiomaterials.com/2022 daily 0.75 2023-04-04 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1641417811638-YQXMIAVYPERAQ5MPBUAQ/TOC+CAR-T-01.png 2022 DELIVERY OF CAR-T CELLS IN A TRANSIENT INJECTABLE STIMULATORY NICHE IMPROVES TREATMENT OF SOLID TUMORS Grosskopf, A.K.^; Labanieh, L.^; Klysz, D.D.; Roth, G.A.; Xu, P.; Adebowale, O.; Gale, E.C.; Jons, C.K.; Klich, J.H.; Yan, J.; Maikawa, C.L.; Correa, S.; Ou, B.S.; d’Aquino, A.I.; Cochran, J.R.; Chaudhuri, O.; Mackall, C.L.*; Appel, E.A.* Science Advances (2022) PDF Check out the Stanford News coverage of this work Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1641417811638-YQXMIAVYPERAQ5MPBUAQ/TOC+CAR-T-01.png 2022 DELIVERY OF CAR-T CELLS IN A TRANSIENT INJECTABLE STIMULATORY NICHE IMPROVES TREATMENT OF SOLID TUMORS Grosskopf, A.K.^; Labanieh, L.^; Klysz, D.D.; Roth, G.A.; Xu, P.; Adebowale, O.; Gale, E.C.; Jons, C.K.; Klich, J.H.; Yan, J.; Maikawa, C.L.; Correa, S.; Ou, B.S.; d’Aquino, A.I.; Cochran, J.R.; Chaudhuri, O.; Mackall, C.L.*; Appel, E.A.* Science Advances (2022) PDF Check out the Stanford News coverage of this work Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1632885156932-PKZZPFWBX95293SQ02LF/908.png 2022 DESIGNING SPATIAL AND TEMPORAL CONTROL OF VACCINE RESPONSES Roth, G.A.; 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Hall, I.A.; Prossnitz, A.N.; Chang, E.; Baker, S.W.; Kasse, C.I.; Jons, C.K.; Yan, J.; Hovgaard, L.; Steensgaard, D.B.; Andersen, H.B.; Simonsen, L.; Appel, E.A.* Cell Reports Medicine (2023) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1675127477800-55ARZFUDKPJ9350XBCUU/892.png 2023 SUSTAINED DELIVERY OF GLP-1 RECEPTOR AGONISTS FROM INJECTABLE BIOMIMETIC HYDROGELS IMPROVES TREATMENT OF DIABETES d’Aquino, A.I.; Maikawa, C.L.; Nguyen, L.T.; Lu, K.; Hall, I.A.; Prossnitz, A.N.; Chang, E.; Baker, S.W.; Kasse, C.I.; Jons, C.K.; Yan, J.; Hovgaard, L.; Steensgaard, D.B.; Andersen, H.B.; Simonsen, L.; Appel, E.A.* Cell Reports Medicine (2023) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1670895554691-OBD2MY0GE8CNU6GPI9B5/895.png 2023 BROAD AND DURABLE HUMORAL RESPONSES FOLLOWING SINGLE HYDROGEL IMMUNIZATION OF SARS-COV-2 SUBUNIT VACCINES Ou, B.S.; 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Maikawa, C.L.; d’Aquino, A.I.; Raghavan, S.S.; Troxell, M.L.; Appel, E.A.* J. Biomed. Mater. Res. Part A. (2023) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1679601910367-YPRN7EDUXBBZUI6JDDLJ/891.png 2023 MICROFLUIDIC ENCAPSULATION OF PHOTOSYNTHETIC CYANOBACTERIA IN HYDROGEL MICROPARTICLES AUGMENTS OXYGEN DELIVERY TO RESCUE ISCHEMIC MYOCARDIUM Stapleton, L.M.; Farry, J.M.; Zhu, Y.; Lucian, H.J.; Wang, H.; Paulsen, M.J.; Totherow, K.P.; Roth, G.A.; Brower, K.K.; Fordyce, P.M.; Appel, E.A.; Woo, Y.J.* J. Biosci. Bioeng. (2023) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1683680942079-HLG0L6RHECBHR6O1MKCF/889.png 2023 INJECTABLE HYDROGELS FOR IMMUNE MODULATION Saouaf, O.M.; d’Aquino, A.I.; Grosskopf, A.K; Appel, E.A.* Biomedical Nanotechnology: Methods and Protocols (2023) https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1699450544985-N1NC4PWUHTBLXDXAOP24/886.png 2023 ANGIOGENIC STEM CELL DELIVERY PLATFORM TO AUGMENT POST-INFARCTION NEOVASCULATURE AND REVERSE VENTRICULAR REMODELING Shin, H.S.; Thakore, A.; Tada, Y.; Pedroza, A.J.; Ikeda, G.; Chen, I.C.; Chan, D.; Jaatinen, K.J.; Yajima, S.; Pfrender, E.M.; Kawamura, M.; Yang, P.C.; Wu, J.C.; Appel, E.A.; Fischbein, M.P.; Woo, Y.J.; Shudo, Y.* Scientific Reports (2023) PDF http://www.supramolecularbiomaterials.com/2024 daily 0.75 2025-04-04 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1689654001054-QB1CVC6L9VRSPB6UG52G/888.png 2024 SAPONIN NANOPARTICLE ADJUVANTS INCORPORATING TOLL-LIKE RECEPTOR AGONISTS IMPROVE VACCINE IMMUNOMODULATION Ou, B.S.^; Baillet, J.^; Filsinger Interrante, M.V.; Adamska, J.S.; Zhou, X.; Saouaf, O.A.; Yan, J.; Klich, J.H.; Jons, C.K.; Meany, E.L.; Valdez, A.; Carter, L.; Pulendran, B.; King, N.P.; Appel, E.A.* Science Advances (2024) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1689654001054-QB1CVC6L9VRSPB6UG52G/888.png 2024 SAPONIN NANOPARTICLE ADJUVANTS INCORPORATING TOLL-LIKE RECEPTOR AGONISTS IMPROVE VACCINE IMMUNOMODULATION Ou, B.S.^; Baillet, J.^; Filsinger Interrante, M.V.; Adamska, J.S.; Zhou, X.; Saouaf, O.A.; Yan, J.; Klich, J.H.; Jons, C.K.; Meany, E.L.; Valdez, A.; Carter, L.; Pulendran, B.; King, N.P.; Appel, E.A.* Science Advances (2024) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1715660318931-N22C53RIGAOM5C5ONMJX/880.png 2024 WATER-ENHANCING GELS EXHIBITING HEAT-ACTIVATED FORMATION OF SILICA AEROGELS FOR PROTECTION OF CRITICAL INFRASTRUCTURE DURING CATASTROPHIC WILDFIRE Dong, C.; d'Aquino, A.I.; Sen, S.; Hall, I.A.; Yu, A.C.; Acosta, J.D.; Appel, E.A.* Advanced Materials (2024) PDF Check out some cool burn videos of our hydrogel technology compared to commercial products! Check out the arXiv preprint here. https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1700905898794-K0XR10R64KDOLYHW6DXE/893.png 2024 NANOPARTICLE-CONJUGATED TLR9 AGONISTS IMPROVE THE POTENCY, DURABILITY, AND BREADTH OF COVID-19 VACCINES Ou, B.S.^; Baillet, J.^; Picece, V.C.T.M.^; Gale, E.C.; Powell, A.E.; Saouaf, O.M.; Yan, J.; Nejatfard, A.; Lopez Hernandez, H.; Appel, E.A.* ACS Nano (2024) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1706532801908-S4O8IZM9RBLS3YFCDJ0U/882.png 2024 BIOMATERIALS TO ENHANCE ADOPTIVE CELL THERAPY Eckman, N.^; Nejatfard, A.^; Cavet, R.; Grosskopf, A.K.*; Appel, E.A.* Nature Reviews Bioengineering (2024) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1625512663194-HFQUJLFQ5OBMASYQHBY2/912.png 2024 A cGAMP-CONTAINING HYDROGEL FOR PROLONGED SARS-COV-2 RBD SUBUNIT VACCINE EXPOSURE INDUCES A BROAD AND POTENT HUMORAL RESPONSE Bohnert, V.^; Gale, E.C.^; Lahey, L.J.^; Yan, J.; Powell, A.E.; Ou, B.S.; Carozza, J.A.; Li, L.*; Appel, E.A.* Advanced NanoBiomed Research (2024) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1702305660775-2HA3UQBP6JG2GPK7IHY4/884.png 2024 BIOMIMETIC NON-ERGODIC AGING BY DYNAMIC-TO-COVALENT TRANSITIONS IN PHYSICAL HYDROGELS Sen, S.; Dong, C.; d’Aquino, A.I.; Yu, A.C.; Appel, E.A.* ACS Applied Materials & Interfaces (2024) PDF Check out the Arxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1723420646053-6U1SI4IHFZ7I66627673/876.png 2024 ELECTROCHEMICALLY MUTABLE SOFT METASURFACES Doshi, S.; Ji, A.; Mahdi, A.I.; Keene, S.T.; Selvin, S.; Lalanne, P.; Appel, E.A.; Melosh, N.A.*; Brongersma, M.L.* Nature Materials (2024) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1701181155078-6KVHF1YKV93T5U646ZQ4/885.png 2024 VIRAL VECTOR ELUTING LENSES FOR SINGLE-STEP TARGETED EXPRESSION OF GENETICALLY-ENCODED ACTIVITY SENSORS FOR IN VIVO MICROENDOSCOPIC CALCIUM IMAGING Jons, C; Cheng, D.; Dong, C.; Meany, E.; Nassi, J.*; Appel, E.A.* Macromolecular Biosciences (2024) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1691820904683-PE3Q4PV6PH7XSBAKZ5TR/887.png 2024 LABEL-FREE COMPOSITION ANALYSIS OF SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS BY REVERSED-PHASE LIQUID CHROMATOGRAPHY COUPLED WITH A CHARGED AEROSOL DETECTOR Tang, S.^; Pederson, Z.^; Meany, E.L.; Yen, C.-W.; Swansiger, A.K.; Prell, J.S.; Chen, B.; Grosskopf, A.K.; Eckman, N.; Jiang, G.; Baillet, J.; Pellett, J.D.; Appel, E.A.* Analytical Chem (2024) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1705100604657-GHB21QHX33LR4GJ3WX49/883.png 2024 COMPOSITE GELS DESIGNED TO STICK TO BIOLOGICAL TISSUES Bailey, S.J.; Appel, E.A.* Nature (2024) PDF Check out the original article in Nature Chem Eng by Prof. Bozhi Tian and coworkers. https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1743733672551-ESYBOS6X64ZFNXFENYWK/858.png 2024 ENGINEERING MATERIALS FOR IMPROVED CULTURE OF HUMAN MESENCHYMAL STEM CELLS Stapleton, L.M.; Chan, D.; Hartmann, F.J.; Bendall, S.C.; Appel, E.A.* PDF This work was peer reviewed but never published because of COVID-related challenges. https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1743733671690-856D0EB43Q2H86G4V4WL/859.png 2024 AN ATLAS OF THE MECHANICAL PROPERTIES OF SOFT ORGANS IN MICE AS MEASURED BY INTERFEROMETRY-BASED NANOINDENTATION Axpe, E.; Chan, D.; Efremov, Y.M.; Correa, S.; Grosskopf, A.K.; Appel, E.A.* PDF This work was peer reviewed but never published because of COVID-related challenges. https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1743733673787-XV1D9NRV36NA39MKNHM4/860.png 2024 TUNING HYDROGEL SURFACE WETTING PROPERTIES VIA BIOMIMETIC IMPRINTING Picece, V.C.T.M.; Chan, D.; Axpe, E.; Cheong, J.C.; Appel, E.A.* PDF This work was peer reviewed but never published because of COVID-related challenges. http://www.supramolecularbiomaterials.com/2025 daily 0.75 2025-12-16 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1725944942769-L7EXBAUPZUYZKB1ROE62/873.png 2025 ULTRA-HIGH CONCENTRATION BIOLOGIC THERAPEUTICS ENABLED BY SPRAY DRYING WITH A GLASSY SURFACTANT EXCIPIENT Jons, C.K.^; 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Chose, M.B.; Jons, C.K.; Dong, C.; Prossnitz, A.N.; Liu, X.; Lopez Hernandez, H.; Cegelski, L.; Appel, E.A.* ACS Central Science (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1727821279918-9P4Y0W1PWWP4WJR6ZBS7/870.png 2025 SUSTAINED EXPOSURE TO MULTIVALENT ANTIGEN-DECORATED NANOPARTICLES GENERATES BROAD ANTI-CORONAVIRUS RESPONSES Baillet, J.^; Klich, J.H.^; Ou, B.S.; Meany, E.L.; Yan, J.; Bruun, T.U.J.; Utz, A.; Jons, C.K.; Lecommandoux, S.; Appel, E.A.* Matter - Cell Press (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1742501013674-3QY7YD5GZFN18ELD4Z7E/862.png 2025 INTUMESCENT POLYMER-PARTICLE HYDROGELS EXPAND THE RETARDANCY WINDOW FOR WILDFIRE DEFENSE Dong, C.; Sen, S.; Ru, Z.; Kolli, A.; Appel, P.S.; Fan, J.; Appel, E.A.* ACS Applied Materials & Interfaces (2025) PDF Check out the Arxiv preprint of this work. https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1722970465103-E6TRLXFKFLNONFAILFQ4/879.png 2025 DEFINING STRUCTURE-FUNCTION RELATIONSHIPS OF AMPHIPHILIC EXCIPIENTS ENABLES RATIONAL DESIGN OF ULTRA-STABLE BIOPHARMACEUTICALS Prossnitz, A.N.; Nguyen, L.T.; Eckman, N.; Borker, S.; Tetef, S.; Autzen, A.A.A.; Fuller, G.G.; Appel, E.A.* Advanced Science (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1742500874271-HSLBWB494QL1C7IVX77P/863.png 2025 CROSSLINK DYNAMICS CONTROL INJECTION FORCE AND FLOW PROFILES OF NON-COVALENT GELS Eckman, N.; Appel, E.A.* Macromolecules (2025) PDF Check out the ChemRxiv preprint of this work. https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1714170206790-4J2DTIPNAH477YMQ2GGL/881.png 2025 SUSTAINED VACCINE EXPOSURE ELICITS MORE RAPID, CONSISTENT, AND BROAD HUMORAL IMMUNE RESPONSES TO MULTIVALENT INFLUENZA VACCINES Saouaf, O.M.; Ou, B.S.; Song, Y.E.; Carter, J.J.; Yan, J.; Jons, C.K.; Barnes, C.O.; Appel, E.A.* Advanced Science (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1722971192871-S3WY4EKHRTT5M9R2KMG2/877.png 2025 HIGHLY EXTENSIBLE PHYSICALLY CROSSLINKED HYDROGELS FOR HIGH-SPEED 3D BIOPRINTING Song, Y.E.; Eckman, N.; Sen, S.; Jon, C.K.; Saouaf, O.M.; Appel, E.A.* Advanced Healthcare Materials (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1748451773049-QE1HOY7UBQB4YGGXGWPG/856.png 2025 HYDROGEL FORMULATIONS FOR SUSTAINED-RELEASE OF BROADLY NEUTRALIZING ANTIBODIES Jons, C.K.; Kasse, C.M.; Mayer, B.T.; Hyrien, O.; Sen, S.; Meany, E.L.; d’Aquino, A.I.; Ganesh, P.; Eckman, N.; Dong, C.; Yan, J.; Nguyen, L.T.; Doulames, V.M.; Song, Y.E.; Saouaf, O.M.; Williams, C.M.; Williams, S.C.; Paredes, J.; Raghavan, R.; Palomares, M.; Alpert, M.; Yates, N.L.; Tomaras, G.D.; Seaman, M.S.; Farzan, M.; Appel, E.A.* Journal of Controlled Release (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1757179108800-Q23REEDYC8LPAQTY416L/853.png 2025 INTRANASAL SERTRALINE FOR THE INVESTIGATION OF NOSE-TO-BRAIN DELIVERY TO MITIGATE SYSTEMIC EXPOSURE Williams, S.C.; Lantz, T.; Doulames, V.; Alakesh, A.; Ramos Mejia, D.; Jons, C.K.; Huang, Z.Y.S.; Eckman, N.; Appel, E.A.* ACS Pharmacology & Translational Science (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1726433926389-M4B3BJXO6E1R5K85XZL8/871.png 2025 A THIOL-ENE CLICK BASED STRATEGY TO CUSTOMIZE INJECTABLE POLYMER-NANOPARTICLE HYDROGEL PROPERTIES FOR THERAPEUTIC DELIVERY Bailey, S.J.; Eckman, N.; Brunel, E.S.; Jons, C.K.; Sen, S.; Appel, E.A.* Biomaterials Science (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1762356621159-7DGWFYLMOPJI42HLZO8O/Pluronic_Vaccines_ToC_Figure.png 2025 ENABLING GLOBAL ACCESS TO POTENT SUBUNIT VACCINES WITH A SIMPLE AND SCALABLE INJECTABLE HYDROGEL PLATFORM Ganesh, P.; Prossnitz, A.N.; Jons, C.K.; Eckman, N.; Alakesh, A.; Song, Y.E.; Sen, S.; Appel, E.A.* Biomaterials Science (2025) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1723839043824-2NIMA3IIX11GGS3S6M5K/874.png 2025 CROSSLINK STRENGTH GOVERNS YIELDING BEHAVIOR IN DYNAMICALLY CROSSLINKED HYDROGELS Eckman, N.; Grosskopf, A.K.; Jiang, G.; Kamani, K.; Huang, M.S.; Schmittlein, B.; Heilshorn, S.C.; Rogers, S.; Appel, E.A.* Biomaterials Science (2025) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1741969154332-0OOU18UZ5XQUO288E5AG/866.png 2025 POSTOPERATIVE ADHESIONS ARE ABROGATED BY A SUSTAINED-RELEASE ANTI-JUN THERAPEUTIC IN PRECLINICAL MODELS Foster, D.S.^; Guo, J.L.^; Meany, E.L.; Berry, C.E.; Fallah, M.; Korah, M.; Januszyk, M.; Bauer-Rowe, K.E.; Lopez, D.M.; Williams, C.M.; Song, R.; Griffin, M.; Kim, A.; Chinta, M.S.; Marshall, C.D.; Wan, D.C.; Hyun, J.S.; Wernig, G.; Norton, J.A.; Appel, E.A.; Delitto, D.*; Longaker, M.T.* Science Translational Medicine (2025) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1743539776875-90OAKDOBQP8Z67NQIT1D/861.png 2025 OSTEOPONTIN ATTENUATES THE FOREIGN-BODY RESPONSE TO SILICONE IMPLANTS Griffin, M.F.; Parker, J.B.; Tevlin, R.; Liang, N.E.; Valencia, C.; Morgan, A.; Kuhnert, M.; Downer Jr., M.; Meany, E.L.; Guo, J.L.; Henn, D.; Navarro, R.S.; Shefren, K.; Nguyen, D.; Gurtner, G.C.; Heilshorn, S.C.; Chan, C.K.F.; Januszyk, M.; Appel, E.A.; Momeni, A.*; Wan, D.C.*; Longaker, M.T.* Nature Biomedical Engineering (2025) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1723668697331-DHVWF60BY0OML2NCDNDQ/875.png 2025 THE CHEMISTRY OF HENNA: A MODULE FOR HIGH SCHOOL STUDENTS Williams, S.C.; Appel, E.A.* Journal of Chemical Education (2025) PDF Check out the arXiv preprint here. https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1734032403782-MJLIMZVIGU0GQSU6VWRM/868.png 2025 CLONALLY EXPANDED, TARGETABLE, NATURAL KILLER-LIKE NKG7 T CELLS SEED THE AGED SPINAL CORD TO DISRUPT MYELOID-DEPENDENT WOUND HEALING G. Kong; Y. Song; Y. Yan; S.M. Calderazzo; M. Sudhana Saddala; F. De Labastida Rivera; J.D. Cherry; N. Eckman; E.A. Appel; A. Velenosi; V. Swarup; R. Kawaguchi; S.S. Ng; B.K. Kwon; D. Gate; C.R. Engwerda; L. Zhou*; S. Di Giovanni* Neuron (2025) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1741969561840-30J51JA2R5LJ70I0ZXRF/865.png 2025 IN VITRO EVALUATION OF GELATIN-BASED HYDROGELS AS POTENTIAL FILLERS FOR CORNEAL WOUNDS Romo-Valera, C.; Appel, E.A.; Etxebarria, J.; Arluzea, J.; Andollo, N.* Biomacromolecules (2025) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1759703613859-ESR0NGVXGVY2MA3YJPD6/852.png 2025 ADVANCING WILDFIRE-RETARDANT MATERIALS: ENGINEERING STRATEGIES FOR DIRECT AND INDIRECT SUPPRESSION Dong, C.; Sen, S.; Kolli, A.; Wilson, S.G.; Appel, E.A.* Advanced Engineering Materials (2025) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1765902719660-Y41QMQA8S6EL82ZJLAV1/849.png 2025 A DEVELOPMENT ROADMAP TOWARD ABDOMINAL ADHESIONS PREVENTION TECHNOLOGIES Christensen, R.R.; Wright, K.E.; Ives, J.K.; Minnick, C.E.; Chen, Q.; Girgis, M.D.; Ko, C.; Gibbons, M.M.; Russell, T.A.; Huy, T.S.; Bercz, A.; Smith, J.J.; Bailey, A.; ten Broek, R.P.G.; de Wilde, R.L.; Zindel, J.; Cardenas, J.C.; Mutsaers, S.; Wiseman, D.; Meany, E.L.; Appel, E.A.; Foster, D.S.; Delitto, D.J.; Longaker, M.T.; Rinkevich, Y.; Bauer, S.R.; Carmichael, S.P.* Annals of Surgery Open (2025) PDF http://www.supramolecularbiomaterials.com/visiting-scholars daily 0.75 2026-01-07 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1750086164065-NQ9SYL34TIOQT5XJSJBY/Manuel.jpg Visiting Scholars MANUEL PEREZ PEREZ Visiting PhD Student, Chemical Science and Technology University of Santiago Compostela, Spain https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1750086164065-NQ9SYL34TIOQT5XJSJBY/Manuel.jpg Visiting Scholars MANUEL PEREZ PEREZ Visiting PhD Student, Chemical Science and Technology University of Santiago Compostela, Spain https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1750085908520-EPOUNUFL8J5TSGL8WVF7/Zuzzana.jpg Visiting Scholars ZUZANNA KRAWCZYK Visiting MS Student, Materials Science EPFL, Switzerland https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1703889730998-6EGO85Z4XU33I2KV2J4L/NJBO_formal+photo.jpg Visiting Scholars NEIL JEAN BORTHWICK Visiting PhD Student, Health Technology Danish Technical University, Denmark https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1646329854852-021C834QRCHN0P6SAM6A/Cristina.jpeg Visiting Scholars CRISTINA ROMO Visiting PhD Student, Biomedical Research University of the Basque Country, Spain https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1583803429005-Q72OJHOW6Q8YIJ9BBIYZ/UNADJUSTEDNONRAW.jpg Visiting Scholars VITTORIA PICECE Visiting MSc Student, Chemistry & Materials Science ETH Zurich, Switzerland https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1759875621622-A305R9NH56FUVSB5WW1V/Jeppe.jpg Visiting Scholars JEPPE ETHELBERG-FINDSEN Visiting PhD Student, Health Technology Danish Technical University, Denmark http://www.supramolecularbiomaterials.com/2026 daily 0.75 2026-04-03 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1740191362752-FKO6CVNJFGKD5LL6FM7F/867.png 2026 PREVENTING PERITENDENOUS ADHESIONS USING LUBRICIOUS SUPRAMOLECULAR HYDROGELS Meany, E.L.^; Williams, C.M.^; Song, Y.E.; Doulames, V.M.; Bailey, S.J.; Williams, S.C.; Jons, C.K.; Fox, P.M.*; Appel, E.A.* Nature Communications (2026) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1740191362752-FKO6CVNJFGKD5LL6FM7F/867.png 2026 PREVENTING PERITENDENOUS ADHESIONS USING LUBRICIOUS SUPRAMOLECULAR HYDROGELS Meany, E.L.^; Williams, C.M.^; Song, Y.E.; Doulames, V.M.; Bailey, S.J.; Williams, S.C.; Jons, C.K.; Fox, P.M.*; Appel, E.A.* Nature Communications (2026) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1751819987140-E1UTPGG4BLZUEU802FW1/855.png 2026 LONG-ACTING HYDROGEL-BASED DEPOT FORMULATIONS OF TIRZEPATIDE AND SEMAGLUTIDE FOR THE MANAGEMENT OF TYPE 2 DIABETES AND WEIGHT d'Aquino, A.I.^; Dong, C.^; Nguyen, L.T.; Yan, J.; Jons, C.K.; Saouaf, O.M.; Song, Y.E.; Eckman, N.; Kapasi, S.; Williams, C.M.; Doulames, V.; Sen, S.; Manna, M.K.; Alakesh, A.; Lu, K.; Hall, I.; Appel, E.A.* Advanced Therapeutics (2026) PDF Check out the BioRxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1748448222088-2LQQXPYCUXTREVIXQHTW/857.png 2026 SPATIALLY TUNED LOCALIZATION OF INTERLEUKINS AND OX40 AGONISTS ENHANCES SYNERGISTIC ANTI-TUMOR IMMUNITY Klich, J.H.; Nejatfard, A.; Meany, E.L.; Ou, B.S.; Baillet, J.; Appel, E.A.* Cell Reports Medicine (2026) PDF https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1742335895459-QHLVIYT5CJFF48AZBV0Z/864.png 2026 EVOLVING TRANSPORT PROPERTIES OF DYNAMIC HYDROGELS ENABLE SELF-TUNING OF SHORT- AND LONG-TERM CARGO DELIVERY Sen, S.^; Dong, C.^; Jons, C.K.; Reineking, W.; Alakesh, A.; Eckman, N.; Song, Y.E.; Prossnitz, A.N.; Appel, E.A.* Journal of Biomaterials Research A (2026) PDF Check out the Arxiv preprint of this work https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1775175669198-V0R61ESZKVG0UMHJWOY4/848.png 2026 A TRANSLATIONAL SURGICAL PORCINE MODEL FOR POSTOPERATIVE INTRA-ABDOMINAL ADHESION FORMATION Reveron-Thornton, R.F.; Hsu, C.-H.; Bobst, W.; Guo, J.L.; Meany, E.L.; Williams, C.M.; Berry, C.; Fallah, M.; Korah, M.; Agolia, J.P.; Guo, C.; Fell, G.L.; Hyun, J.; Wan, D.C.; Norton, J.A.; Appel, E.A.; Longaker, M.T.; Delitto, D.*; Foster, D.S.* Journal of Visualized Experiments (2026) PDF http://www.supramolecularbiomaterials.com/members daily 0.75 2025-06-16 http://www.supramolecularbiomaterials.com/about daily 0.75 2015-08-14 https://images.squarespace-cdn.com/content/v1/52f83177e4b045fae914ddf2/1392171611837-4R41OYO88W2WPZ4Y1X4Z/AppelFamily.jpg About Photo courtesy of acostaphotography.com 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It will plot them on the figure and also calculate the relevant pressures and flow rates under your constraints. The pressure and shear rate are calculated at the minimum flow rate indicated, where the pressure should be less than the maximum pressure for an extrudable material. 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